Pyridine

Base Information

• Chemical Name: Pyridine
• CAS No.: 110-86-1
• Deprecated CAS: 152758-95-7,163392-20-9,45410-39-7,62301-32-0,6999-00-4,82005-06-9,85404-19-9,85404-20-2,733733-47-6,857961-06-9,163392-20-9,45410-39-7,62301-32-0,6999-00-4,733733-47-6,82005-06-9,85404-19-9,85404-20-2,857961-06-9
• Molecular Formula: C5H5N
• Molecular Weight: 79.1014
• Hs Code.: 2933990090
• European Community (EC) Number: 203-809-9
• ICSC Number: 0323
• NSC Number: 141574,406123
• UN Number: 1282
• UNII: NH9L3PP67S
• DSSTox Substance ID: DTXSID9021924
• Nikkaji Number: J1.672.061E,J2.883E,J2.792.623A
• Wikipedia: Pyridine
• Wikidata: Q210385
• Pharos Ligand ID: 3SJKT1UK5JW2
• Metabolomics Workbench ID: 37503
• ChEMBL ID: CHEMBL266158
• Mol file: 110-86-1.mol

Synonyms:monopyridine phosphate;pyridine;pyridine cyanate;pyridine dinitrate;pyridine diphosphate;pyridine disulfate;pyridine hydride;pyridine hydride (2:1);pyridine hydrochloride;pyridine ion (1-), hydrogen;pyridine ion (1-), lithium salt;pyridine ion (1-), potassium salt;pyridine ion (1-), sodium salt;pyridine ion (2+);pyridine monohydrate;pyridine monophosphate;pyridine monosulfate;pyridine nitrate;pyridine perbromate, 82Br-labeled;pyridine perchlorate;pyridine perchlorate, 2H-labeled;pyridine phosphate;pyridine phosphate (2:1);pyridine sulfate;pyridine sulfate (2:1);pyridine, hydrogen bromide;pyridine, hydrogen fluoride;pyridine, hydrogen iodide

Chemical Property of Pyridine

Chemical Property:

• Appearance/Colour: Colorless to light yellow liquid
• Vapor Pressure: 18 mm Hg @ at 20°C
• Melting Point: -42 °C
• Refractive Index: n20/D 1.509(lit.)
• Boiling Point: 115.3 °C at 760 mmHg
• PKA: 5.23±0.10(Predicted)
• Flash Point: 17 °C
• PSA: 12.89000
• Density: 0.978 g/cm³
• LogP: 1.08160
• Water Solubility.: Miscible
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 79.042199164
• Heavy Atom Count: 6
• Complexity: 30.9
• Transport DOT Label: Flammable Liquid

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s): T,N,F,Xn
• Hazard Codes: F:Flammable;;
• Statements: R11:; R20/21/22:
• Safety Statements: S26:; S28A:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Pyridines
• Canonical SMILES: C1=CC=NC=C1
• Inhalation Risk: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.
• Effects of Long Term Exposure: This substance is possibly carcinogenic to humans.

Technology Process of Pyridine

There total 1074 articles about Pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(E)-2-pyridylphenyl ketoxime (14178-31-5) → pyridine (110-86-1) + [2,2]bipyridinyl (366-18-7) + 2-(2'-pyridyl)benzoxazole (32959-62-9) + benzonitrile (100-47-0)

Guidance literature:

at 800 ℃; for 8.33333E-06h; under 0.001 Torr; Further byproducts given;

Reference yield: 62.0%

1-(4-nitrophenylthio)pyridinium chloride → pyridine (110-86-1) + 4-nitrobenzenesulfenyl chloride (937-32-6) + di(p-nitrophenyl) disulfide (100-32-3)

Guidance literature:

at 120 ℃; Product distribution;

DOI:10.1039/c39810000703

Reference yield: 44.0%

3-dimethylaminopyridine (18437-57-5) + chloroform (67-66-3,8013-54-5) → pyridine (110-86-1) + 3-Chloropyridine (626-60-8) + pyridine-3-carbonitrile (100-54-9,121697-66-3,1232169-17-3,68271-95-4)

Guidance literature:

at 550 ℃;

upstream raw materials:

piperidine

silver(I) acetate

acetic acid

nitrobenzene

Downstream raw materials:

2-((Z)-3-Phenyl-allylidene)-malonic acid

5-phenyl-2,4-pentadienoic acid

3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-ylamine

2,3-(methylenedioxy)cinnamic acid

Refernces

• 1、 Janczak, Jan,Kubiak, Ryszard. "Stereochemistry and properties of the M(II)-N(py) coordination bond in the low-spin dipyridinated iron(II) and cobalt(II) phthalocyanines". . p. 64 - 76. Retrieved 2003.
• 2、 Budnikova,Kargin. "Electrochemical reduction of halopyridines catalyzed by Ni0(bipy)2". . p. 128 - 131. Retrieved 2001.
• 3、 Chen, Zhou,Mesgar, Milad,White, Peter S.,Daugulis, Olafs,Brookhart, Maurice. "Synthesis of branched ultrahigh-molecular-weight polyethylene using highly active neutral, single-component Ni(II) catalysts". . p. 631 - 636. Retrieved 2015.
• 4、 Blues et al.. "". . p. 466. Retrieved 1974.
• 5、 Achey, Darren,Ardo, Shane,Meyer, Gerald J.. "Increase in the coordination number of a cobalt porphyrin after photo-induced interfacial electron transfer into nanocrystalline TiO2". . p. 9865 - 9872. Retrieved 2012.
• 6、 Clerici, A.,Porta, O.. "REDUCTIVE DECYANATION OF PYRIDINECARBONITRILES BY TITANIUM TRICHLORIDE". . p. 1675 - 1676. Retrieved 1980.
• 7、 Brown,Rao. "-". . p. 3164. Retrieved 1955.
• 8、 Ovchenkova,Bichan,Lomova. "Synthesis and properties of a new (octaethylporphyrinato)-manganese(III)–pyridinyl-substituted pyrrolidinofullerene dyad". . p. 1503 - 1508. Retrieved 2016.
• 9、 Marshall, David B.,Eyring, Edward M.,Strohbusch, Frank,White, Robert D.. "Acid-Base Kinetics of Pyridine Studied with a Slow Spectrophotometric Indicator in Methanol". . p. 7065 - 7067. Retrieved 1980.
• 10、 Gutmann, Bernhard,Schwan, Alexander M.,Reichart, Benedikt,Gspan, Christian,Hofer, Ferdinand,Kappe, C. Oliver. "Activation and deactivation of a chemical transformation by an electromagnetic field: Evidence for specific microwave effects in the formation of grignard reagents". . p. 7636 - 7640. Retrieved 2011.