N-[3-(trifluoromethyl)phenyl]nicotinamide

Base Information

Chemical Name:N-[3-(trifluoromethyl)phenyl]nicotinamide
CAS No.:24303-04-6
Molecular Formula:C13H9 F3 N2 O
Molecular Weight:266.222
Hs Code.:
NSC Number:131172
DSSTox Substance ID:DTXSID80299531
Wikidata:Q82041990
ChEMBL ID:CHEMBL1609038
Mol file:24303-04-6.mol

Synonyms:N-[3-(trifluoromethyl)phenyl]nicotinamide;N-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide;24303-04-6;N-(3-(trifluoromethyl)phenyl)nicotinamide;NSC131172;Maybridge1_008926;MLS000061187;SCHEMBL5178391;CHEMBL1609038;HMS566N16;DTXSID80299531;ZVCOVVQEHPKTCS-UHFFFAOYSA-N;HMS2435E20;STK096922;AKOS000629682;NSC-131172;SDCCGMLS-0043991.P002;SMR000069255;SR-01000392568;SR-01000392568-1;Z28169806;F1472-0154

Suppliers and Price of N-[3-(trifluoromethyl)phenyl]nicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N-[3-(trifluoromethyl)phenyl]nicotinamide

Chemical Property:

Vapor Pressure:0.00632mmHg at 25°C
Boiling Point:271.8°C at 760 mmHg
Flash Point:118.2°C
Density:1.364g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:266.06669740
Heavy Atom Count:19
Complexity:320

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)NC(=O)C2=CN=CC=C2)C(F)(F)F

Technology Process of N-[3-(trifluoromethyl)phenyl]nicotinamide

There total 4 articles about N-[3-(trifluoromethyl)phenyl]nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 401-81-0
m-trifluoromethylphenyl iodide

: 98-92-0,1255150-40-3
nicotinamide

: 24303-04-6
N-(3-(trifluoromethyl)phenyl)nicotinamide

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 80 ℃; for 12h; Inert atmosphere;
DOI:10.1002/aoc.3933

Reference yield: 74.0%

: 626-55-1,163928-56-1
3-Bromopyridine

: 98-16-8
3-trifluoromethylaniline

: 13939-06-5,199620-15-0
molybdenum hexacarbonyl

: 24303-04-6
N-(3-(trifluoromethyl)phenyl)nicotinamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 120 ℃; for 3h; Sealed tube; Inert atmosphere;
DOI:10.1055/s-0037-1609152

Reference yield: 43.0%

: 59-67-6
nicotinic acid

: 98-16-8
3-trifluoromethylaniline

: 24303-04-6
N-(3-(trifluoromethyl)phenyl)nicotinamide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 72h;
DOI:10.1371/journal.pone.0149317