3',4'-Dihydroxyflavone

Base Information

• Chemical Name: 3',4'-Dihydroxyflavone
• CAS No.: 4143-64-0
• Molecular Formula: C15H10O4
• Molecular Weight: 254.242
• Hs Code.: 2914501900
• UNII: KOH101S66V
• DSSTox Substance ID: DTXSID70194349
• Nikkaji Number: J354.017K
• Wikidata: Q27282353
• Pharos Ligand ID: R97KU3BT93N4
• Metabolomics Workbench ID: 74493
• ChEMBL ID: CHEMBL222556
• Mol file: 4143-64-0.mol

Synonyms:3',4'-dihydroxy-flavone;3',4'-dihydroxyflavone

Chemical Property of 3',4'-Dihydroxyflavone

Chemical Property:

• Melting Point: 251-253 °C
• Boiling Point: 482.3 °C at 760 mmHg
• PKA: 8.29±0.18(Predicted)
• Flash Point: 188.4 °C
• PSA: 70.67000
• Density: 1.443 g/cm³
• LogP: 2.87120
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 254.05790880
• Heavy Atom Count: 19
• Complexity: 390

Purity/Quality:

97% ^*data from raw suppliers

3'',4''-Dihydroxyflavone ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)C=C(O2)C3=CC(=C(C=C3)O)O

Technology Process of 3',4'-Dihydroxyflavone

There total 17 articles about 3',4'-Dihydroxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-(2-hydroxy-phenyl)-propane-1,3-dione → 3',4'-dihydroxyflavone (4143-64-0)

Guidance literature:

With sulfuric acid; In acetic acid; at 95 - 100 ℃; for 1h;

DOI:10.1021/jo00016a015

Reference yield: 68.0%

3',4'-dimethoxyflavone (4143-62-8) → 3',4'-dihydroxyflavone (4143-64-0)

Guidance literature:

With pyridine hydrochloride; at 140 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmcl.2017.03.057

Reference yield: 62.0%

2-[3,4-di(benzyloxy)phenyl]-4H-chromen-4-one → 3',4'-dihydroxyflavone (4143-64-0)

Guidance literature:

With 10% palladium hydroxide on charcoal; hydrogen; In ethanol; at 60 ℃; for 1h;

DOI:10.3987/COM-13-S(S)107

upstream raw materials:

3',4'-dimethoxyflavone

(E)-2'-hydroxy-3,4-dimethoxychalcone

o-hydroxyacetophenone

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

3,3',4'-trihydroxyflavone

3',4'-dihydroxyflavone-4'-phosphate

Refernces

Synthesis of new glycosylated flavonoids with inhibitory activity on cell growth

10.3390/molecules23051093

The research focuses on the synthesis and biological evaluation of new glycosylated flavonoids and xanthones with inhibitory activity on cell growth. The study involves the synthesis of four flavonoids (compounds 5, 6, 9, and 10) and one xanthone (compound 7) containing acetoglycoside moieties. Key chemicals used in the synthesis include rutin, diosmin, mangiferin, and 3,4-dihydroxyflavone as starting materials. Acetic anhydride and microwave irradiation were employed for acetylation, while 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide was used as the glucose donor for glycosylation. The synthesized compounds were evaluated for their in vitro cell growth inhibitory activity against six human tumor cell lines, including A375-C5, MCF-7, NCI-H460, U251, U373, and U87MG. The results showed that compound 10 exhibited the most potent inhibitory activity across all tested cell lines, with GI50 values < 8 μM and notable selectivity for cancer cells. The study highlights the importance of both acetylation and glycosylation in enhancing the biological activity of these compounds, providing insights for future development of more effective antitumor agents.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 4143-64-0 3',4'-Dihydroxyflavone

Send

Send

Metric Ton KG G Pound L ML

Send

Send