N-(4-amino-2-methylquinolin-6-yl)-2-phenylacetamide

Base Information

Chemical Name:N-(4-amino-2-methylquinolin-6-yl)-2-phenylacetamide
CAS No.:7511-77-5
Molecular Formula:C₁₈H₁₇N₃O
Molecular Weight:291.352
Hs Code.:
NSC Number:33351
DSSTox Substance ID:DTXSID80283778
Wikidata:Q82018470
ChEMBL ID:CHEMBL3098988

Synonyms:CHEMBL3098988;7511-77-5;NSC33351;N-(4-amino-2-methylquinolin-6-yl)-2-phenylacetamide;DTXSID80283778;BDBM50444731;NSC-33351

Suppliers and Price of N-(4-amino-2-methylquinolin-6-yl)-2-phenylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of N-(4-amino-2-methylquinolin-6-yl)-2-phenylacetamide

Chemical Property:

Vapor Pressure:5.29E-14mmHg at 25°C
Boiling Point:592.3°C at 760 mmHg
Flash Point:312°C
Density:1.271g/cm³
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:291.137162174
Heavy Atom Count:22
Complexity:381

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C2C=C(C=CC2=N1)NC(=O)CC3=CC=CC=C3)N

Technology Process of N-(4-amino-2-methylquinolin-6-yl)-2-phenylacetamide

There total 9 articles about N-(4-amino-2-methylquinolin-6-yl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1528735-41-2
C₂₈H₃₃N₃O₅

: 76-05-1
trifluoroacetic acid

: 7511-77-5
N-(4-amino-2-methylquinolin-6-yl)-2-phenylacetamide

Guidance literature:: In dichloromethane;
DOI:10.1016/j.bmc.2013.11.009

Reference yield:

: 5443-31-2
2-methyl-quinoline-4,6-diamine

: 103-80-0
phenylacetyl chloride

: 7511-77-5
N-(4-amino-2-methylquinolin-6-yl)-2-phenylacetamide

Guidance literature:: With acetic acid;
DOI:10.1021/ja01596a041

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 7511-77-5
N-(4-amino-2-methylquinolin-6-yl)-2-phenylacetamide

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid / tetralin / 1 h / 150 - 210 °C / Inert atmosphere

2: trichlorophosphate / water / 0.5 h / Reflux; Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

4: triphenylphosphine / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

5: pyridine / 1 h / 60 °C / Inert atmosphere

6: ammonium formate; 5%-palladium/activated carbon / methanol / 20 h / 20 °C / Inert atmosphere

7: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

8: dichloromethane

With pyridine; sodium azide; sulfuric acid; 5%-palladium/activated carbon; ammonium formate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; trichlorophosphate; In tetrahydrofuran; methanol; tetralin; dichloromethane; water; N,N-dimethyl-formamide; 4: |Staudinger Azide Reduction;
DOI:10.1016/j.bmc.2013.11.009