Chemical Property of 3'-Carbamoyl-[1,1'-biphenyl]-3-yl cyclohexylcarbamate
Chemical Property:
- Appearance/Colour:white powder
- Boiling Point:533.2 °C at 760 mmHg
- PKA:11.74±0.20(Predicted)
- Flash Point:276.3 °C
- PSA：81.42000
- Density:1.23 g/cm3
- LogP:4.96480
- Storage Temp.:2-8°C
- Solubility.:DMSO: ~14 mg/mL, soluble
- XLogP3:3.8
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:5
- Exact Mass:338.16304257
- Heavy Atom Count:25
- Complexity:462
- Purity/Quality:
-
99% *data from raw suppliers
URB 597 *data from reagent suppliers
Safty Information:
- Pictogram(s):
N
- Hazard Codes:N
- Statements:
50/53
- Safety Statements:
22-24/25-60-61
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CCC(CC1)NC(=O)OC2=CC=CC(=C2)C3=CC(=CC=C3)C(=O)N
- Recent ClinicalTrials:Evaluation Study of New Compounds With Potential Use in Schizophrenia
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Description
URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1. URB-597 (546141-08-6) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, IC50 = 3-5 nM.1?Produces cannabinoid CB1 and CB2 receptor-mediated analgesia in inflammatory pain states without causing side effects associated with cannabinoid receptor activation.2?Attenuates the anxiolytic-like effect of acetaminophen in a mouse model.3?Exerts anti-inflammatory effects in rat hippocampus and ameliorates age-related deficits.4?Off target effects of URB-597: Reduces tyrosine hydroxylase expression.5 Improves cognitive?impairment caused by chronic cerebral hypoperfusion in a mouse model via inhibition of mTOR-dependent autophagy.6
