glutamyl-aspartyl-glycine

Base Information

• Chemical Name: glutamyl-aspartyl-glycine
• CAS No.: 75007-24-8
• Molecular Formula: C₁₁H₁₇N₃O₈
• Molecular Weight: 319.271
• Mol file: 75007-24-8.mol

Synonyms:Glycine,N-(N-L-a-glutamyl-L-a-aspartyl)-; Glu-Asp-Gly-OH

Chemical Property of glutamyl-aspartyl-glycine

Chemical Property:

• Vapor Pressure: 1E-31mmHg at 25°C
• Melting Point: 143 - 145 °C
• Boiling Point: 847.2°C at 760 mmHg
• Flash Point: 466.2°C
• PSA: 196.12000
• Density: 1.518g/cm³
• LogP: -1.17910

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of glutamyl-aspartyl-glycine

There total 9 articles about glutamyl-aspartyl-glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Z-Glu(OBzl)-Asp(OBzl)-Gly-OBzl → H-Glu-Asp-Gly-OH (75007-24-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In water; acetic acid; for 12h;

DOI:10.1248/cpb.28.1629

Reference yield: 89.0%

N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester (101559-55-1) → H-Glu-Asp-Gly-OH (75007-24-8)

Guidance literature:

With dimethylsulfide; trifluorormethanesulfonic acid; trifluoroacetic acid; In various solvent(s);

DOI:10.1016/j.bmc.2004.06.012

Reference yield:

C16H25N3O10 → H-Glu-Asp-Gly-OH (75007-24-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester

benzyl (3S)-4-{[2-(benzyloxy)-2-oxoethyl]amino}-3-[(tert-butoxycarbonyl)amino]-4-oxobutanoate

N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid

(S)-2-tert-Butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-(2,5-dioxo-pyrrolidin-1-yl) ester

Refernces

• 1、 Wang, Chao,Zhao, Ming,Qiu, Xuecai,Peng, Shiqi. "The synthesis and immunosuppressive activities of steroid-urotoxin linkers". . p. 4403 - 4421. Retrieved 2007/10/03.