N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester

Base Information

Chemical Name:N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester
CAS No.:101559-55-1
Molecular Formula:C₃₇H₄₃N₃O₁₀
Molecular Weight:689.763
Hs Code.:

Synonyms:N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester

Suppliers and Price of N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester

Chemical Property:

Purity/Quality:: 99% ，98% ^*data from raw suppliers

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Technology Process of N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester

There total 6 articles about N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 13574-13-5
Boc-Glu(OBzl)-OH

: Asp(OBzl)-Gly-OBzl hydrochloride

: 101559-55-1
N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester

Guidance literature:: Asp(OBzl)-Gly-OBzl hydrochloride; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 24h;

Boc-Glu(OBzl)-OH; With 4-methyl-morpholine; In tetrahydrofuran;
DOI:10.1016/j.bmc.2004.06.012

Reference yield: 85.0%

: N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartate

: 1738-76-7
glycine benzyl ester p-toluenesulfonic acid salt

: 101559-55-1
N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; at -10 - 20 ℃; for 27.17h;

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 101559-55-1
N-tert-butyloxycarbonyl(γ-benzyl)glutamyl(β-benzyl)aspartylglycine benzene ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: HOBt; DCC / tetrahydrofuran / 24 h / 0 °C

1.2: 80 percent / N-methylmorpholine / tetrahydrofuran

2.1: 91 percent / hydrogen chloride / ethyl acetate / 3 h / 20 °C

3.1: HOBt; DCC / tetrahydrofuran / 24 h / 0 °C

3.2: 87 percent / N-methylmorpholine / tetrahydrofuran

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate;
DOI:10.1016/j.bmc.2004.06.012