2,4-Pyrimidinediamine,5-[[4-[3-[[4-[(4-aminophenyl)sulfonyl]phenyl]amino]propoxy]-3,5-dimethoxyphenyl]methyl]-

Base Information

• Chemical Name: 2,4-Pyrimidinediamine,5-[[4-[3-[[4-[(4-aminophenyl)sulfonyl]phenyl]amino]propoxy]-3,5-dimethoxyphenyl]methyl]-
• CAS No.: 111452-88-1
• Molecular Formula: C28H32 N6 O5 S
• Molecular Weight: 564.665
• Mol file: 111452-88-1.mol

Synonyms:K 130; K130 (pharmaceutical)

Chemical Property of 2,4-Pyrimidinediamine,5-[[4-[3-[[4-[(4-aminophenyl)sulfonyl]phenyl]amino]propoxy]-3,5-dimethoxyphenyl]methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Pyrimidinediamine,5-[[4-[3-[[4-[(4-aminophenyl)sulfonyl]phenyl]amino]propoxy]-3,5-dimethoxyphenyl]methyl]-

There total 5 articles about 2,4-Pyrimidinediamine,5-[[4-[3-[[4-[(4-aminophenyl)sulfonyl]phenyl]amino]propoxy]-3,5-dimethoxyphenyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(3,5-Dimethoxy-4-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine (111452-84-7) → 2,4-diamino-5-<4-<3-(4''-aminophenyl-4'-sulphonylphenylamino)propoxy>-3,5-dimethoxybenzyl>pyrimidine (111452-88-1)

Guidance literature:

With hydrogen; Raney Ni (W₂); In methanol; 2-methoxy-ethanol; at 50 ℃; for 1.33333h; under 3750.3 Torr; Yield given;

DOI:10.1016/0223-5234(92)90007-N

Reference yield:

4'-nitro-4-N-tosylaminodiphenyl sulfide (111453-03-3) → 2,4-diamino-5-<4-<3-(4''-aminophenyl-4'-sulphonylphenylamino)propoxy>-3,5-dimethoxybenzyl>pyrimidine (111452-88-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / CuI, aq. KOH / ethanol / 2 h / Heating

2: 94 percent / concd H₂O₂, glacial AcOH / 4 h / 65 °C

3: 97 percent / concd H₂SO₄ / 1 h / Ambient temperature

4: 51 percent / Na / 2-methoxy-ethanol / 8 h / 60 °C

5: H₂ / Raney Ni (W₂) / 2-methoxy-ethanol; methanol / 1.33 h / 50 °C / 3750.3 Torr

With potassium hydroxide; copper(l) iodide; sulfuric acid; hydrogen; dihydrogen peroxide; sodium; acetic acid; Raney Ni (W₂); In methanol; ethanol; 2-methoxy-ethanol;

DOI:10.1016/0223-5234(92)90007-N

Reference yield:

4--4'-nitrodiphenylsulphone (111453-08-8) → 2,4-diamino-5-<4-<3-(4''-aminophenyl-4'-sulphonylphenylamino)propoxy>-3,5-dimethoxybenzyl>pyrimidine (111452-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / Na / 2-methoxy-ethanol / 8 h / 60 °C

2: H₂ / Raney Ni (W₂) / 2-methoxy-ethanol; methanol / 1.33 h / 50 °C / 3750.3 Torr

With hydrogen; sodium; Raney Ni (W₂); In methanol; 2-methoxy-ethanol;

DOI:10.1016/0223-5234(92)90007-N

upstream raw materials:

5-(3,5-Dimethoxy-4-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine

4'-nitro-4-N-tosylaminodiphenyl sulfide

4--4'-nitrodiphenylsulphone

4--4'-nitrodiphenylsulphide