4-Methyl-3,7-dihydrofuro[2,3-b]pyridin-6(2h)-one

Base Information

• Chemical Name: 4-Methyl-3,7-dihydrofuro[2,3-b]pyridin-6(2h)-one
• CAS No.: 22385-34-8
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.165
• NSC Number: 132867
• DSSTox Substance ID: DTXSID90299789
• Wikidata: Q82042443
• Mol file: 22385-34-8.mol

Synonyms:4-methyl-3,7-dihydrofuro[2,3-b]pyridin-6(2h)-one;22385-34-8;4-methyl-3,7-dihydro-2H-furo[2,3-b]pyridin-6-one;NSC132867;DTXSID90299789;NSC-132867;4-methyl-6-hydroxy-2,3-dihydro-7-azabenzofuran

Chemical Property of 4-Methyl-3,7-dihydrofuro[2,3-b]pyridin-6(2h)-one

Chemical Property:

• Vapor Pressure: 1.88E-07mmHg at 25°C
• Boiling Point: 425.7°C at 760 mmHg
• Flash Point: 211.2°C
• Density: 1.24g/cm³
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 276

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)NC2=C1CCO2

Technology Process of 4-Methyl-3,7-dihydrofuro[2,3-b]pyridin-6(2h)-one

There total 11 articles about 4-Methyl-3,7-dihydrofuro[2,3-b]pyridin-6(2h)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzylammonium salt of 2,6-dihydroxy-3-(β-hydroxyethyl)-4-methyl-5-cyanopyridine (94145-19-4) → 2,3-Dihydro-4-methyl-furo<2.3-b>pyridon-(6) (22385-34-8)

Guidance literature:

With sulfuric acid; for 6h; Heating;

DOI:10.1007/BF00513579

Reference yield:

→ 2,3-Dihydro-4-methyl-furo<2.3-b>pyridon-(6) (22385-34-8)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01257a025 DOI:10.1039/j39690001678

Reference yield:

ammonium salt of 2,6-dihydroxy-3-(β-hydroxyethyl)-4-methyl-5-cyanopyridine (94145-20-7) → 2,3-Dihydro-4-methyl-furo<2.3-b>pyridon-(6) (22385-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / 4 h / 150 - 160 °C

2: 86 percent / diluted H₂SO₄ / 6 h / Heating

With sulfuric acid;

DOI:10.1007/BF00513579

upstream raw materials:

benzylammonium salt of 2,6-dihydroxy-3-(β-hydroxyethyl)-4-methyl-5-cyanopyridine

ammonium salt of 2,6-dihydroxy-3-(β-hydroxyethyl)-4-methyl-5-cyanopyridine

hydrogenchloride

2,6-dihydroxy-5-(2-hydroxy-ethyl)-4-methyl-nicotinonitrile

Downstream raw materials:

2-5-Dichloro-3-(β-chlorethyl)-4-methylpyridin