(Des-pyr1)-lhrh

Base Information

• Chemical Name: (Des-pyr1)-lhrh
• CAS No.: 38280-53-4
• Molecular Formula: C₅₀H₇₀N₁₆O₁₁
• Molecular Weight: 1071.21
• European Community (EC) Number: 636-809-6
• DSSTox Substance ID: DTXSID20191661
• ChEMBL ID: CHEMBL3304720
• Mol file: 38280-53-4.mol

Synonyms:des (pGlu(1))-LHRH;des 1 GnRH;LHRH (2-10);LHRH (2-10), acetate

Chemical Property of (Des-pyr1)-lhrh

Chemical Property:

• PSA: 439.95000
• Density: 1.51 g/cm³
• LogP: 1.65190
• Storage Temp.: −20°C
• XLogP3: -2.5
• Hydrogen Bond Donor Count: 15
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 29
• Exact Mass: 1070.54099711
• Heavy Atom Count: 77
• Complexity: 2060

Purity/Quality:

99% ^*data from raw suppliers

(Des-Pyr 1)-LHRH acetate salt H-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 acetate salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 60
• Safety Statements: 53-22-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)N
• Isomeric SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)N

Technology Process of (Des-pyr1)-lhrh

There total 3 articles about (Des-pyr1)-lhrh which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

gonadotropin releasing hormone (33515-09-2,51988-59-1,53634-19-8,53634-20-1,53634-21-2,53634-22-3,53728-75-9,64693-15-8,70920-45-5,103065-82-3) → L-histidyl-L-tryptophanyldiketopiperazine (18610-65-6,108391-80-6,133397-85-0,18610-64-5) + 103065-82-3 + 53634-19-8 + pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-OH (35263-73-1) + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (38280-53-4) + 35925-21-4

Guidance literature:

With water; at 50 ℃; for 2160h; Product distribution; pH = 6.5; var. temp. and times of degradation;

DOI:10.1002/jps.2600800504

Reference yield:

BOC-glycine (4530-20-5) + 1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + Boc-Arg(Tos)-OH (13836-37-8) → His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (38280-53-4)

Guidance literature:

Multistep reaction;

DOI:10.1248/cpb.54.827

Reference yield:

→ His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (38280-53-4)

Guidance literature:

entspr. geschuetztes Nonapeptid, Na/NH3;

DOI:10.1016/0006-291X(73)91325-9

upstream raw materials:

gonadotropin releasing hormone

BOC-glycine

1-(tert-butoxycarbonyl)-L-proline

N-tert-butoxycarbonyl-L-leucine