2,4-DICHLOROQUINOLINE

Base Information

• Chemical Name: 2,4-DICHLOROQUINOLINE
• CAS No.: 703-61-7
• Molecular Formula: C9H5Cl2N
• Molecular Weight: 198.051
• Hs Code.: 2933499090
• Mol file: 703-61-7.mol

Synonyms:2,4-Dichlorochinoline;2,4-Dichloroquinoline;

Chemical Property of 2,4-DICHLOROQUINOLINE

Chemical Property:

• Vapor Pressure: 0.00623mmHg at 25°C
• Melting Point: 52-54 °C
• Refractive Index: 1.66
• Boiling Point: 281 °C at 760 mmHg
• PKA: -1.10±0.50(Predicted)
• Flash Point: 154.2 °C
• PSA: 12.89000
• Density: 1.407 g/cm³
• LogP: 3.54160
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dichloroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38-41-37/38-25
• Safety Statements: 26-36-45-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Dichloroquinoline is used in the synthesis of tRNA synthetase inhibitors with antibacterial activity against gram-positive bacteria. Also used in the preparation of arylquinolines displaying anthelmintic properties.

Technology Process of 2,4-DICHLOROQUINOLINE

There total 34 articles about 2,4-DICHLOROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,4-dibromoquinoline (20151-40-0) → 2,4-dichloroquinoline (703-61-7)

Guidance literature:

With hydrogenchloride; In acetonitrile; at 20 ℃; for 24h;

DOI:10.1023/A:1015331531268

Reference yield: 96.0%

2,4-dihydroxyquinoline (70254-44-3) → 2,4-dichloroquinoline (703-61-7)

Guidance literature:

With trichlorophosphate; for 6h; Heating / reflux;

Reference yield: 90.0%

4-Hydroxy-2-quinolone (70254-43-2,70254-44-3,86-95-3) → 2,4-dichloroquinoline (703-61-7)

Guidance literature:

With triethylamine; trichlorophosphate; at 40 - 90 ℃; for 1.08333h;

DOI:10.1021/acs.jmedchem.9b01585

upstream raw materials:

α-oxyquinoline 1-oxide

4-hydroxy-1-methyl-2(1H)-quinolone

4-nitroquinoline-N-oxide

1-benzyloxy-1H-quinolin-4-one

Downstream raw materials:

2,4-dimorpholiniquinoline

2-Chloro-4-ethoxyquinoline

4-chloro-2-ethoxyquinoline

2,4-diethoxyquinoline

Refernces

• 1、 Elbastawesy, Mohammed A. I.,El-Shaier, Yaseen A. M. M.,Ramadan, Mohamed,Brown, Alan B.,Aly, Ashraf A.,Abuo-Rahma, Gamal El-Din A.. "Identification and molecular modeling of new quinolin-2-one thiosemicarbazide scaffold with antimicrobial urease inhibitory activity". . p. 13 - 27. Retrieved 2020/01/22.
• 2、 Henley, Zo? A.,Amour, Augustin,Barton, Nick,Bantscheff, Marcus,Bergamini, Giovanna,Bertrand, Sophie M.,Convery, Máire,Down, Kenneth,Dümpelfeld, Birgit,Edwards, Chris D.,Grandi, Paola,Gore, Paul M.,Keeling, Steve,Livia, Stefano,Mallett, David,Maxwell, Aoife,Price, Mark,Rau, Christina,Reinhard, Friedrich B. M.,Rowedder, James,Rowland, Paul,Taylor, Jonathan A.,Thomas, Daniel A.,Hessel, Edith M.,Hamblin, J. Nicole. "Optimization of Orally Bioavailable PI3KδInhibitors and Identification of Vps34 as a Key Selectivity Target". supporting information. p. 638 - 655. Retrieved 2020/02/04.