4'-Chloro-beta-methyl-1-piperidinepropionanilide

Base Information

Chemical Name:4'-Chloro-beta-methyl-1-piperidinepropionanilide
CAS No.:108971-38-6
Molecular Formula:C15H21 Cl N2 O
Molecular Weight:280.793
Hs Code.:
DSSTox Substance ID:DTXSID00910938

Synonyms:BRN 0214254;4'-Chloro-beta-methyl-1-piperidinepropionanilide;1-Piperidinepropionanilide, 4'-chloro-beta-methyl-;108971-38-6;DTXSID00910938;LS-116118;N-(4-CHLOROPHENYL)-3-(PIPERIDIN-1-YL)BUTANAMIDE

Suppliers and Price of 4'-Chloro-beta-methyl-1-piperidinepropionanilide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4'-Chloro-beta-methyl-1-piperidinepropionanilide

Chemical Property:

Vapor Pressure:2.53E-08mmHg at 25°C
Boiling Point:451°C at 760 mmHg
Flash Point:226.5°C
Density:1.174g/cm³
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:280.1342410
Heavy Atom Count:19
Complexity:284

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC(=O)NC1=CC=C(C=C1)Cl)N2CCCCC2

Technology Process of 4'-Chloro-beta-methyl-1-piperidinepropionanilide

There total 3 articles about 4'-Chloro-beta-methyl-1-piperidinepropionanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 106-47-8
4-chloro-aniline

: (+/-)-3-(1-piperidinyl)butyric acid

: 108971-38-6
3-piperidino-butyric acid-(4-chloro-anilide)

Guidance literature:: 4-chloro-aniline; (+/-)-3-(1-piperidinyl)butyric acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/acs.orglett.1c00704

Reference yield:

: 110-89-4
piperidine

: 108971-38-6
3-piperidino-butyric acid-(4-chloro-anilide)

Guidance literature:: Multi-step reaction with 2 steps

1.1: water / 9 h / 75 °C / Inert atmosphere

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/acs.orglett.1c00704