Clibucaine

Base Information

Chemical Name:Clibucaine
CAS No.:15302-10-0
Molecular Formula:C15H20 Cl2 N2 O
Molecular Weight:315.24
Hs Code.:2933399090
Mol file:15302-10-0.mol

Synonyms:1-Piperidinepropionanilide,2',4'-dichloro-b-methyl-(6CI,8CI); 2',4'-Dichloro-b-piperidinobutyranilide; Clibucaine

Suppliers and Price of Clibucaine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
CLIBUCAINE 95.00%
5MG
$ 497.00

Total 6 raw suppliers

Chemical Property of Clibucaine

Chemical Property:

Vapor Pressure:6.86E-09mmHg at 25°C
Boiling Point:466.8°Cat760mmHg
PKA:13.02±0.70(Predicted)
Flash Point:236.1°C
PSA：35.83000
Density:1.255g/cm³
LogP:4.78380

Purity/Quality:

99% ^*data from raw suppliers

CLIBUCAINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Clibucaine

There total 6 articles about Clibucaine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 108971-38-6
3-piperidino-butyric acid-(4-chloro-anilide)

: 15302-10-0
N-(2,4-dichlorophenyl)-3-(piperidin-1-yl)butanamide

Guidance literature:: With tetraethylammonium chloride; trichloroacetonitrile; In acetonitrile; at 23 ℃; for 2h; Electrochemical reaction; Inert atmosphere;
DOI:10.1021/acs.orglett.1c00704

Reference yield:

: 110-89-4
piperidine

: 15302-10-0
N-(2,4-dichlorophenyl)-3-(piperidin-1-yl)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water / 9 h / 75 °C / Inert atmosphere

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: trichloroacetonitrile; tetraethylammonium chloride / acetonitrile / 2 h / 23 °C / Electrochemical reaction; Inert atmosphere

With dmap; tetraethylammonium chloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichloroacetonitrile; In dichloromethane; acetonitrile;
DOI:10.1021/acs.orglett.1c00704

Reference yield:

: (+/-)-3-(1-piperidinyl)butyric acid

: 15302-10-0
N-(2,4-dichlorophenyl)-3-(piperidin-1-yl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trichloroacetonitrile; tetraethylammonium chloride / acetonitrile / 2 h / 23 °C / Electrochemical reaction; Inert atmosphere

With dmap; tetraethylammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichloroacetonitrile; In dichloromethane; acetonitrile;
DOI:10.1021/acs.orglett.1c00704