1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

Base Information

• Chemical Name: 1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione
• CAS No.: 120040-38-2
• Molecular Formula: C16H22 N2 O5
• Molecular Weight: 322.36
• Mol file: 120040-38-2.mol

Synonyms:1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

Chemical Property of 1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

Chemical Property:

• Vapor Pressure: 2.43E-12mmHg at 25°C
• Boiling Point: 554.6°Cat760mmHg
• Flash Point: 289.2°C
• PSA: 80.59000
• Density: 1.18g/cm³
• LogP: 0.73390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione

There total 5 articles about 1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.3%

(Z)-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione (120063-29-8) → 1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione (120040-38-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 4h; under 760 Torr;

DOI:10.1248/cpb.36.2607

Reference yield:

(Z)-1-acetyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione (113296-74-5) → 1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione (120040-38-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) sodium hydride / 1.) DMF, 0 deg C, 30 min; 2.) DMF, 25 deg C, 12 h

2: 50.2 percent / hydrazine hydrate / dimethylformamide / 1 h / 25 °C

3: 1.) sodium hydride / 1.) DMF, 0 deg C, 30 min; 2.) DMF, 25 deg C, 1 h

4: 69 percent / H₂SO₄ / trifluoroacetic acid / 12 h / 25 °C

5: 68.3 percent / hydrogen / 20percent palladium on carbon / ethanol / 4 h / 760 Torr

With sulfuric acid; hydrogen; sodium hydride; hydrazine hydrate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; trifluoroacetic acid;

DOI:10.1248/cpb.36.2607

Reference yield:

(Z)-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione (120040-36-0) → 1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione (120040-38-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) sodium hydride / 1.) DMF, 0 deg C, 30 min; 2.) DMF, 25 deg C, 1 h

2: 69 percent / H₂SO₄ / trifluoroacetic acid / 12 h / 25 °C

3: 68.3 percent / hydrogen / 20percent palladium on carbon / ethanol / 4 h / 760 Torr

With sulfuric acid; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; trifluoroacetic acid;

DOI:10.1248/cpb.36.2607

upstream raw materials:

(Z)-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

(Z)-1-acetyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

(Z)-4-(4-methoxyphenylmethyl)-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

(Z)-4-(4-methoxyphenylmethyl)-1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethylene)-2,5-piperazinedione

Downstream raw materials:

1-methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-4-isopropyloxycarbonyl-2,5-piperazinedione

1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-5-thioxo-2-piperazinone

6-Hydroxy-4-methyl-3-oxo-2-(2,4,5-trimethoxy-3-methyl-benzyl)-piperazine-1-carboxylic acid isopropyl ester

1-Methyl-3-(3-methyl-2,4,5-trimethoxyphenylmethyl)-2-piperazinone