cyclic(3-1)-1-(carboxymethyl)prolyl-phenylalanyl-histidinamide

Base Information

Chemical Name:cyclic(3-1)-1-(carboxymethyl)prolyl-phenylalanyl-histidinamide
CAS No.:132235-85-9
Molecular Formula:C22H25 N5 O5
Molecular Weight:439.471
Hs Code.:
Mol file:132235-85-9.mol

Synonyms:cyclic(3-1)-1-(carboxymethyl)prolyl-phenylalanyl-histidinamide

Suppliers and Price of cyclic(3-1)-1-(carboxymethyl)prolyl-phenylalanyl-histidinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of cyclic(3-1)-1-(carboxymethyl)prolyl-phenylalanyl-histidinamide

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:919.8°Cat760mmHg
PKA:2.73±0.40(Predicted)
Flash Point:510.1°C
PSA：140.61000
Density:1.49g/cm³
LogP:0.21680

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of cyclic(3-1)-1-(carboxymethyl)prolyl-phenylalanyl-histidinamide

There total 7 articles about cyclic(3-1)-1-(carboxymethyl)prolyl-phenylalanyl-histidinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 132235-84-8
(8S,11S,14S)-11-Benzyl-3,9,12-trioxo-1,4,10,13,17-pentaaza-tricyclo[14.2.1.0^4,8]nonadeca-16⁽¹⁹⁾,17-diene-14-carboxylic acid benzyl ester

: 132235-85-9
(8S,11S,14S)-11-Benzyl-3,9,12-trioxo-1,4,10,13,17-pentaaza-tricyclo[14.2.1.0^4,8]nonadeca-16⁽¹⁹⁾,17-diene-14-carboxylic acid

Guidance literature:: With ammonium formate; palladium on activated charcoal; In N,N-dimethyl-formamide; for 18h;
DOI:10.1021/jm00108a006

Reference yield:

: 52071-65-5
N-tert-butyloxycarbonyl-L-prolyl-L-phenylalanine

: 132235-85-9
(8S,11S,14S)-11-Benzyl-3,9,12-trioxo-1,4,10,13,17-pentaaza-tricyclo[14.2.1.0^4,8]nonadeca-16⁽¹⁹⁾,17-diene-14-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: diisopropylethylamine, diethylphosphoryl cyanide / CH₂Cl₂ / 18 h

2: 100 percent / 1-hydroxybenzotriazole / methanol / 18 h

3: 72 percent / diisopropylethylamine / CH₂Cl₂ / 18 h

4: 100 percent / diisopropylethylamine / CH₂Cl₂ / 1.25 h

5: 78 percent / 4-(dimethylamino)pyridine, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 120 h

6: 100 percent / ammonium formate / 5percent Pd/C / dimethylformamide / 18 h

With dmap; diethylphosphoryl cyanide; ammonium formate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a006

Reference yield:

: 132259-58-6
N^α-(tert-butyloxycarbonyl)-L-prolyl-L-phenylalanyl-N^im-<(tert-butyloxycarbonyl)methyl>-L-histidine benzyl ester

: 132235-85-9
(8S,11S,14S)-11-Benzyl-3,9,12-trioxo-1,4,10,13,17-pentaaza-tricyclo[14.2.1.0^4,8]nonadeca-16⁽¹⁹⁾,17-diene-14-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / diisopropylethylamine / CH₂Cl₂ / 1.25 h

2: 78 percent / 4-(dimethylamino)pyridine, benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate / CH₂Cl₂ / 120 h

3: 100 percent / ammonium formate / 5percent Pd/C / dimethylformamide / 18 h

With dmap; ammonium formate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00108a006