2,3-DIHYDRO-1H-INDEN-5-YLACETIC ACID

Base Information

• Chemical Name: 2,3-DIHYDRO-1H-INDEN-5-YLACETIC ACID
• CAS No.: 5453-98-5
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.215
• Hs Code.: 2916399090
• Mol file: 5453-98-5.mol

Synonyms:Indan-5-acetic acid;2,3-dihydro-1h-inden-5-ylacetic acid;2-indan-5-ylacetic acid;5-indaneacetic acid;5-Indanacetic acid;Indan-5-yl-essigsaeure;Indan-5-yl-acetic acid;

Chemical Property of 2,3-DIHYDRO-1H-INDEN-5-YLACETIC ACID

Chemical Property:

• Vapor Pressure: 5.56E-05mmHg at 25°C
• Melting Point: 113-114 °C
• Boiling Point: 333°Cat760mmHg
• PKA: 4.40±0.10(Predicted)
• Flash Point: 230.1°C
• PSA: 37.30000
• Density: 1.207g/cm³
• LogP: 1.80240
• Storage Temp.: 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

2,3-Dihydro-1H-inden-5-ylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-DIHYDRO-1H-INDEN-5-YLACETIC ACID

There total 7 articles about 2,3-DIHYDRO-1H-INDEN-5-YLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-Indan-5-yl-1-morpholin-4-yl-ethanethione (158094-20-3) → indan-5-yl acetic acid (5453-98-5)

Guidance literature:

With potassium hydroxide; for 20h; Heating;

DOI:10.1021/jm00047a006

Reference yield:

→ indan-5-yl acetic acid (5453-98-5)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01174a003

Reference yield:

indan-5-yl-acetic acid ethyl ester (858225-07-7) → indan-5-yl acetic acid (5453-98-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 15h;

DOI:10.1016/j.bmcl.2019.126838

upstream raw materials:

2-Indan-5-yl-1-morpholin-4-yl-ethanethione

indan-5-amine

2,3-dihydro-5-iodo-1H-indene

indan-5-yl-acetic acid ethyl ester

Refernces

• 1、 Young, Jonathan R.,Huang, Song X.,Chen, Irene,Walsh, Thomas F.,DeVita, Robert J.,Wyvratt Jr., Matthew J.,Goulet, Mark T.,Ren, Ning,Lo, Jane,Yang, Yi Tien,Yudkovitz, Joel B.,Cheng, Kang,Smith, Roy G.. "Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents". . p. 1723 - 1727. Retrieved 2007/10/03.