(3S,αR)-3-[[[(E)-Hydroxyimino](4-hydroxyphenyl)acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid

Base Information

Chemical Name:(3S,αR)-3-[[[(E)-Hydroxyimino](4-hydroxyphenyl)acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid
CAS No.:63598-46-9
Molecular Formula:C₁₉H₁₇N₃O₇
Molecular Weight:399.36
Hs Code.:

Synonyms:Nocardicin F;3-<2-(4-hydroxyphenyl)-2-(hydroxyimino)acetamido>nocardicinic acid;

Suppliers and Price of (3S,αR)-3-[[[(E)-Hydroxyimino](4-hydroxyphenyl)acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NocardicinF
50mg
$ 17600.00

Medical Isotopes, Inc.
NocardicinF
50 mg
$ 17000.00

Total 5 raw suppliers

Chemical Property of (3S,αR)-3-[[[(E)-Hydroxyimino](4-hydroxyphenyl)acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid

Chemical Property:

Melting Point:230-231 °C (decomp)
PKA:3.46±0.10(Predicted)
PSA：159.76000
Density:1.57g/cm³
LogP:0.75780

Purity/Quality:

99% ^*data from raw suppliers

NocardicinF ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Nocardicin F is a β-lactam antibiotic.

Technology Process of (3S,αR)-3-[[[(E)-Hydroxyimino](4-hydroxyphenyl)acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid

There total 4 articles about (3S,αR)-3-[[[(E)-Hydroxyimino](4-hydroxyphenyl)acetyl]amino]-α-(4-hydroxyphenyl)-2-oxo-1-azetidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61425-19-2,61425-20-5,73618-22-1,75261-15-3
nocardicin A sodium salt

: 63598-46-9,63555-59-9
3-<2-(4-hydroxyphenyl)-2-(hydroxyimino)acetamido>nocardicinic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 84.8 percent / H₂ / Pd-C (10percent)

2: 78.1 percent / H₂O; pyridine / 1 h / Ambient temperature; pH 9

3: 40 percent / concd. HCl / acetic acid / 0.5 h / 10 °C

4: 1.) PCl₅; 2.) N,N-bis(trimethylsilyl)acetamide / 1.) benzene, 0-5 deg C, 1 h; 2.) CH₂Cl₂, 0-5 deg C, 1 h

With hydrogenchloride; phosphorus pentachloride; hydrogen; N,N-bis(trimethylsilyl)acetamide; palladium on activated charcoal; In pyridine; water; acetic acid;
DOI:10.1248/cpb.35.3979

Reference yield:

: 59511-12-5,75283-26-0,99297-17-3,99297-18-4
nocardicin C

: 63598-46-9,63555-59-9
3-<2-(4-hydroxyphenyl)-2-(hydroxyimino)acetamido>nocardicinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 78.1 percent / H₂O; pyridine / 1 h / Ambient temperature; pH 9

2: 40 percent / concd. HCl / acetic acid / 0.5 h / 10 °C

3: 1.) PCl₅; 2.) N,N-bis(trimethylsilyl)acetamide / 1.) benzene, 0-5 deg C, 1 h; 2.) CH₂Cl₂, 0-5 deg C, 1 h

With hydrogenchloride; phosphorus pentachloride; N,N-bis(trimethylsilyl)acetamide; In pyridine; water; acetic acid;
DOI:10.1248/cpb.35.3979

Reference yield:

: 59510-70-2,121787-01-7,122921-03-3
bis(phenylthioureido)nocardicin C

: 63598-46-9,63555-59-9
3-<2-(4-hydroxyphenyl)-2-(hydroxyimino)acetamido>nocardicinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / concd. HCl / acetic acid / 0.5 h / 10 °C

2: 1.) PCl₅; 2.) N,N-bis(trimethylsilyl)acetamide / 1.) benzene, 0-5 deg C, 1 h; 2.) CH₂Cl₂, 0-5 deg C, 1 h

With hydrogenchloride; phosphorus pentachloride; N,N-bis(trimethylsilyl)acetamide; In acetic acid;
DOI:10.1248/cpb.35.3979