3-aminonocardicinic acid

Base Information

• Chemical Name: 3-aminonocardicinic acid
• CAS No.: 67509-41-5
• Molecular Formula: C11H12N2O4
• Molecular Weight: 236.227
• Mol file: 67509-41-5.mol

Synonyms:2-[(3S)-3-amino-2-oxoazetidin-1-yl]-2-(4-hydroxyphenyl)acetic acid;

Chemical Property of 3-aminonocardicinic acid

Chemical Property:

• Vapor Pressure: 8.45E-13mmHg at 25°C
• Boiling Point: 547°C at 760 mmHg
• Flash Point: 284.6°C
• PSA: 103.86000
• Density: 1.526g/cm³
• LogP: 0.32560

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-aminonocardicinic acid

There total 13 articles about 3-aminonocardicinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzhydryl O-benzyl-3-aminonocardicinate → 3-aminonocardicinic acid hydrochloride (67509-41-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; for 6h; under 760 Torr; Ambient temperature;

DOI:10.1246/bcsj.55.1234

Reference yield: 86.0%

N,O-Bis(t-butoxycarbonyl)-3-amino-nocardicinsaure (73888-88-7) → 3-aminonocardicinic acid hydrochloride (67509-41-5)

Guidance literature:

With trifluoroacetic acid; at 0 - 5 ℃; for 0.133333h;

DOI:10.1002/hlca.19800630202

Reference yield: 60.4%

(3S,αR)-2-(2-oxo-3-phthalimido-1-azetidinyl)-2-(4-hydroxyphenyl)acetic acid (71336-86-2) → 3-aminonocardicinic acid hydrochloride (67509-41-5)

Guidance literature:

With 1-amino-3-(dimethylamino)propane; In methanol; for 8h; Ambient temperature;

DOI:10.1248/cpb.35.3985

upstream raw materials:

(3S,αR)-2-(2-oxo-3-phthalimido-1-azetidinyl)-2-(4-hydroxyphenyl)acetic acid

benzyl O-benzyl-3-aminonocardicinate

bis(phenylthioureido)nocardicin C

N,O-Bis(t-butoxycarbonyl)-3-amino-nocardicinsaure

Downstream raw materials:

3-<2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido>nocardicinic acid

3-<(4-hydroxyphenyl)glyoxyloylamino>nocardicinic acid sodium salt

2-<3-(2-hydroxyimino-2-phenylacetamido)-2-oxo-1-azetidinyl>-2-(4-hydroxyphenyl)acetic acid

3-<2-(4-hydroxyphenyl)-2-(hydroxyimino)acetamido>nocardicinic acid