Udp-adfg

Base Information

Chemical Name:Udp-adfg
CAS No.:120596-20-5
Molecular Formula:C17H26 F N3 O16 P2 . 2 Li
Molecular Weight:621.216
Hs Code.:
Mol file:120596-20-5.mol

Synonyms:UDP-ADFG;uridine 5'-(2-acetamido-2,4-dideoxy-4-fluoro-alpha-D-galactopyranosyl)diphosphate;uridine 5'-(2-acetamido-2,4-dideoxy-4-fluorogalactopyranosyl)diphosphate

Suppliers and Price of Udp-adfg

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Udp-adfg

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：314.66000
Density:g/cm³
LogP:-2.10940
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:10
Exact Mass:621.0935907
Heavy Atom Count:41
Complexity:1060

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:[Li+].[Li+].CC(=O)NC1C(C(C(OC1OP(=O)([O-])OP(=O)([O-])OCC2C(C(C(O2)N3C=CC(=O)NC3=O)O)O)CO)F)O
Isomeric SMILES:[Li+].[Li+].CC(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@@H]1OP(=O)([O-])OP(=O)([O-])OC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC(=O)NC3=O)O)O)CO)F)O

Technology Process of Udp-adfg

There total 8 articles about Udp-adfg which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120615-74-9
Acetic acid (2R,3R,4R,5R,6R)-2-acetoxymethyl-5-acetylamino-3-fluoro-6-phosphonooxy-tetrahydro-pyran-4-yl ester

: 27908-36-7
uridine 5'-monophosphate morpholidate

: 120596-20-5
dilithium uridine 5'-(2-acetamido-2,4-dideoxy-4-fluoro-α-D-galactopyranosyl)diphosphate

Guidance literature:: With lithium hydroxide; sodium hydroxide; Yield given. Multistep reaction; 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h;
DOI:10.1016/0008-6215(88)80007-7

Reference yield:

: 55287-49-5
benzyl 2-acetamido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranoside

: 120596-20-5
dilithium uridine 5'-(2-acetamido-2,4-dideoxy-4-fluoro-α-D-galactopyranosyl)diphosphate

Guidance literature:: Multi-step reaction with 8 steps

1: 75 percent / pyridine / 24 h / 4 °C

2: 59 percent / tetrabutylammonium fluoride / acetonitrile / 72 h / Heating

3: H₂ / 10percent Pd-C / acetic acid / 24 h / 2587.7 Torr / Ambient temperature

4: pyridine / 24 h / Ambient temperature

5: 85 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 44 h / 50 °C

6: 32 percent / 1,2-dichloro-ethane / 24 h / Ambient temperature

7: 88 percent / H₂ / Pd-C / methanol / 1 h / Ambient temperature

8: 2.) M NaOH, 3.) M LiOH / 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h

With pyridine; lithium hydroxide; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In methanol; acetic acid; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/0008-6215(88)80007-7

Reference yield:

: 129728-87-6,129728-92-3
2-acetamido-2,4-dideoxy-4-fluoro-D-galactopyranose

: 120596-20-5
dilithium uridine 5'-(2-acetamido-2,4-dideoxy-4-fluoro-α-D-galactopyranosyl)diphosphate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 24 h / Ambient temperature

2: 85 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 44 h / 50 °C

3: 32 percent / 1,2-dichloro-ethane / 24 h / Ambient temperature

4: 88 percent / H₂ / Pd-C / methanol / 1 h / Ambient temperature

5: 2.) M NaOH, 3.) M LiOH / 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h

With pyridine; lithium hydroxide; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; hydrogen; palladium on activated charcoal; In methanol; 1,2-dichloro-ethane;
DOI:10.1016/0008-6215(88)80007-7