methyl 4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazole-5-carboxylate

Base Information

Chemical Name:methyl 4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazole-5-carboxylate
CAS No.:108905-63-1
Molecular Formula:C₇H₉BrN₂O₂S
Molecular Weight:265.131
Hs Code.:
Mol file:108905-63-1.mol

Synonyms:methyl 4-bromo-1-methyl-2-(methylsulfanyl)-1h-imidazole-5-carboxylate;Methyl 5-bromo-3-methyl-2-methylsulfanyl-imidazole-4-carboxylate;Methyl 4-bromo-1-methyl-2-methylthio-5-imidazolecarboxylate;1H-Imidazole-5-carboxylicacid,4-bromo-1-methyl-2-(methylthio)-,methyl ester;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazole-5-carboxylate

Chemical Property:

Vapor Pressure:1.06E-05mmHg at 25°C
Boiling Point:371°C at 760 mmHg
PKA:0.29±0.60(Predicted)
Flash Point:178.2°C
PSA：69.42000
Density:1.65g/cm³
LogP:1.69110

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of methyl 4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazole-5-carboxylate

There total 2 articles about methyl 4-bromo-1-methyl-2-(methylsulfanyl)-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 77410-17-4
methyl 1-methyl-2-(methylsulphanyl)-1H-imidazole-5-carbpxylate

: 108905-63-1
Methyl 4-bromo-1-methyl-2-methylthio-5-imidazolecarboxylate

Guidance literature:: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; chloroform; at 65 ℃; for 15h;
DOI:10.1055/s-1988-27702

Reference yield:

: 68892-07-9
1-methyl-5-carbomethoxy-2-thio-imidazole

: 108905-63-1
Methyl 4-bromo-1-methyl-2-methylthio-5-imidazolecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / K₂CO₃ / methanol / 0.03 h / Ambient temperature

2: 46 percent / NBS / AIBN / CHCl₃; CCl₄ / 15 h / 65 °C

With N-Bromosuccinimide; potassium carbonate; 2,2'-azobis(isobutyronitrile); In methanol; tetrachloromethane; chloroform;
DOI:10.1055/s-1988-27702

Reference yield:

: 123-32-0
2,5-dimethyl-pyrazine

: 108905-63-1
Methyl 4-bromo-1-methyl-2-methylthio-5-imidazolecarboxylate

: 108905-64-2
2-(5-methyl-2-pyrazinyl)-1-(4-bromo-1-methyl-2-(methylthio)-5-imidazolyl)ethan-1-one

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1) THF, hexanes, -78 deg C, 2) -19 to -15 deg C;
DOI:10.1021/jo00031a017