3-[(3,5-dichlorobenzoyl)amino]-3-methyl-2-oxobutanoic acid

Base Information

Chemical Name:3-[(3,5-dichlorobenzoyl)amino]-3-methyl-2-oxobutanoic acid
CAS No.:31110-51-7
Molecular Formula:C12H11 Cl2 N O4
Molecular Weight:304.126
Hs Code.:
Mol file:31110-51-7.mol

Synonyms:Butyricacid, 3-(3,5-dichlorobenzamido)-3-methyl-2-oxo- (8CI); b-(3,5-Dichlorobenzamido)-b-methyl-a-ketobutyric acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[(3,5-dichlorobenzoyl)amino]-3-methyl-2-oxobutanoic acid

Chemical Property:

Vapor Pressure:2.38E-08mmHg at 25°C
Boiling Point:435.3°C at 760 mmHg
PKA:2.40±0.54(Predicted)
Flash Point:217.1°C
PSA：86.96000
Density:1.437g/cm³
LogP:2.73030

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-[(3,5-dichlorobenzoyl)amino]-3-methyl-2-oxobutanoic acid

There total 5 articles about 3-[(3,5-dichlorobenzoyl)amino]-3-methyl-2-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 31110-42-6
3-(3,5-dichloro-benzoylamino)-2-hydroxy-3-methylbutyric acid

: 31110-51-7
3-(3,5-dichloro-benzoylamino)-3-methyl-2-oxo-butyric acid

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -60 - -50 ℃; for 0.5h;
DOI:10.1021/jf0107196

Reference yield:

: 2905-62-6
3,5-dichlorobenzoyl chloride

: 31110-51-7
3-(3,5-dichloro-benzoylamino)-3-methyl-2-oxo-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. NaOH / toluene / 2 h / 20 °C

1.2: NaOH / ethanol / 3 h / Heating

2.1: 68 percent / aq. HCl; NaNO₂ / dioxane / 20 °C

3.1: 77 percent / oxalyl chloride; DMSO / CH₂Cl₂ / 0.5 h / -60 - -50 °C

With hydrogenchloride; sodium hydroxide; oxalyl dichloride; dimethyl sulfoxide; sodium nitrite; In 1,4-dioxane; dichloromethane; toluene;
DOI:10.1021/jf0107196

Reference yield:

: 3-amino-2-hydroxy-3-methylbutyramide hydrochloride

: 31110-51-7
3-(3,5-dichloro-benzoylamino)-3-methyl-2-oxo-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. NaOH / toluene / 2 h / 20 °C

1.2: NaOH / ethanol / 3 h / Heating

2.1: 68 percent / aq. HCl; NaNO₂ / dioxane / 20 °C

3.1: 77 percent / oxalyl chloride; DMSO / CH₂Cl₂ / 0.5 h / -60 - -50 °C

With hydrogenchloride; sodium hydroxide; oxalyl dichloride; dimethyl sulfoxide; sodium nitrite; In 1,4-dioxane; dichloromethane; toluene;
DOI:10.1021/jf0107196