Urea, N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(1-methyl-1H-indol-3-yl)cyclohexyl)methyl)-

Base Information

Chemical Name:Urea, N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(1-methyl-1H-indol-3-yl)cyclohexyl)methyl)-
CAS No.:145131-25-5
Molecular Formula:C₂₉H₃₉N₃O
Molecular Weight:445.648
Hs Code.:
DSSTox Substance ID:DTXSID20162896
Nikkaji Number:J759.419D
Wikidata:Q83031687
Mol file:145131-25-5.mol

Synonyms:145131-25-5;Urea, N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(1-methyl-1H-indol-3-yl)cyclohexyl)methyl)-;N-(2,6-Bis(1-methylethyl)phenyl)-N'-((1-(1-methyl-1H-indol-3-yl)cyclohexyl)methyl)urea;N(sup 1)-(2,6-Diisopropylphenyl)-N(sup 2)-(1-(1-methyl-3-indolyl)cyclohexylmethyl)urea;1-[2,6-di(propan-2-yl)phenyl]-3-[[1-(1-methylindol-3-yl)cyclohexyl]methyl]urea;DTXSID20162896;YIZUGMRAJJBEBN-UHFFFAOYSA-N;LS-159102;N-[[1-(1-Methyl-1H-indol-3-yl)cyclohexyl]methyl]-N'-(2,6-diisopropylphenyl)urea

Suppliers and Price of Urea, N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(1-methyl-1H-indol-3-yl)cyclohexyl)methyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Urea, N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(1-methyl-1H-indol-3-yl)cyclohexyl)methyl)-

Chemical Property:

Vapor Pressure:4.2E-13mmHg at 25°C
Boiling Point:572.2°C at 760 mmHg
PKA:13.91±0.46(Predicted)
Flash Point:299.9°C
PSA：49.55000
Density:1.1g/cm³
LogP:7.72610
XLogP3:7.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:6
Exact Mass:445.309312876
Heavy Atom Count:33
Complexity:625

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1=C(C(=CC=C1)C(C)C)NC(=O)NCC2(CCCCC2)C3=CN(C4=CC=CC=C43)C

Technology Process of Urea, N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(1-methyl-1H-indol-3-yl)cyclohexyl)methyl)-

There total 4 articles about Urea, N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(1-methyl-1H-indol-3-yl)cyclohexyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 145132-16-7
C-[1-(1-Methyl-1H-indol-3-yl)-cyclohexyl]-methylamine

: 2,2,2-trichloro-N-(2,6-diisopropylphenyl)acetamide

: 145131-25-5
1-(2,6-Diisopropyl-phenyl)-3-[1-(1-methyl-1H-indol-3-yl)-cyclohexylmethyl]-urea

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; Heating;
DOI:10.1016/0223-5234(96)80445-4

Reference yield:

: 771-51-7
indole-3-acetonitrile

: 145131-25-5
1-(2,6-Diisopropyl-phenyl)-3-[1-(1-methyl-1H-indol-3-yl)-cyclohexylmethyl]-urea

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / triton B, aq. NaOH / methanol / 3 h / Ambient temperature

2: 58 percent / NaH / dimethylsulfoxide; diethyl ether / 4 h / Heating

3: 53 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / Heating

4: 85 percent / K₂CO₃ / dimethylformamide / Heating

With sodium hydroxide; lithium aluminium tetrahydride; N-benzyl-trimethylammonium hydroxide; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(96)80445-4

Reference yield:

: 51584-17-9
1-methyl-1H-indole-3-acetonitrile

: 145131-25-5
1-(2,6-Diisopropyl-phenyl)-3-[1-(1-methyl-1H-indol-3-yl)-cyclohexylmethyl]-urea

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / NaH / dimethylsulfoxide; diethyl ether / 4 h / Heating

2: 53 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / Heating

3: 85 percent / K₂CO₃ / dimethylformamide / Heating

With lithium aluminium tetrahydride; sodium hydride; potassium carbonate; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(96)80445-4