(2-Ethoxyphenyl)urea

Base Information

• Chemical Name: (2-Ethoxyphenyl)urea
• CAS No.: 148-70-9
• Molecular Formula: C9H12 N2 O2
• Molecular Weight: 180.206
• DSSTox Substance ID: DTXSID20163863
• Wikidata: Q83032850
• Mol file: 148-70-9.mol

Synonyms:(2-Ethoxyphenyl)urea;1-(2-ethoxyphenyl)urea;148-70-9;o-Phenetylurea;Urea, (o-ethoxyphenyl)-;(o-Ethoxyphenyl)urea;BRN 2722883;Urea, (2-ethoxyphenyl)-;AI3-61310;4-13-00-00850 (Beilstein Handbook Reference);SCHEMBL1791238;DTXSID20163863;MFCD00995172;STL124164;AKOS000153942;BS-3980;LS-160120

Chemical Property of (2-Ethoxyphenyl)urea

Chemical Property:

• Vapor Pressure: 0.00152mmHg at 25°C
• Boiling Point: 295.5°C at 760 mmHg
• Flash Point: 132.5°C
• Density: 1.199g/cm³
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 180.089877630
• Heavy Atom Count: 13
• Complexity: 173

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1NC(=O)N

Technology Process of (2-Ethoxyphenyl)urea

There total 5 articles about (2-Ethoxyphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-ethoxybenzamide (938-73-8) → 1-(2-ethoxyphenyl)urea (148-70-9)

Guidance literature:

With [bis(acetoxy)iodo]benzene; ammonia; In methanol; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0040-1707103

Reference yield:

potassium cyanate (590-28-3) + ortho-phenitidine (94-70-2) → 1-(2-ethoxyphenyl)urea (148-70-9)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01373a507

Reference yield:

ortho-phenitidine (94-70-2) → 1-(2-ethoxyphenyl)urea (148-70-9)

Guidance literature:

Multi-step reaction with 2 steps

2: aqueous KOH-solution

With potassium hydroxide;

upstream raw materials:

N-acetyl-N'-(2-ethoxy-phenyl)-urea

potassium cyanate

ortho-phenitidine

2-ethoxybenzamide

Refernces

• 1、 Franck, Xavier,Glachet, Thomas,Ibert, Quentin,Lohier, Jean-Fran?ois,Reboul, Vincent,Saraiva Rosa, Nathalie. "A Straightforward Synthesis of N-Substituted Ureas from Primary Amides". . p. 2099 - 2105. Retrieved 2020/07/13.