Ethenzamide

Base Information

• Chemical Name: Ethenzamide
• CAS No.: 938-73-8
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 29242995
• European Community (EC) Number: 213-346-4
• NSC Number: 28787
• UNII: L929ZCK4BF
• DSSTox Substance ID: DTXSID4020581
• Nikkaji Number: J3.352I
• Wikipedia: Ethenzamide
• Wikidata: Q553324
• NCI Thesaurus Code: C87323
• Metabolomics Workbench ID: 154341
• ChEMBL ID: CHEMBL1483877
• Mol file: 938-73-8.mol

Synonyms:2-ethoxy-benzamide;2-ethoxybenzamide;ethenzamide;o-ethoxybenzamide

Chemical Property of Ethenzamide

Chemical Property:

• Appearance/Colour: white to almost white granular crystalline powder
• Vapor Pressure: 0.00102mmHg at 25°C
• Melting Point: 129-134 °C
• Refractive Index: 1.538
• Boiling Point: 302 °C at 760 mmHg
• PKA: 15.62±0.50(Predicted)
• Flash Point: 153.7 °C
• PSA: 52.32000
• Density: 1.111 g/cm³
• LogP: 1.88450
• Storage Temp.: Store below +30°C.
• Solubility.: Chloroform (Slightly), Dichloromethane (Slightly)
• Water Solubility.: <0.1 g/100 mL at 16℃
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 165.078978594
• Heavy Atom Count: 12
• Complexity: 159

Purity/Quality:

99% ^*data from raw suppliers

2-Ethoxybenzamide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1C(=O)N

Technology Process of Ethenzamide

There total 24 articles about Ethenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-ethoxybenzonitrile (6609-57-0) → 2-ethoxybenzamide (938-73-8)

Guidance literature:

With [2,2]bipyridinyl; water; palladium diacetate; In 1,4-dioxane; at 90 ℃; for 24h; Schlenk technique; Sealed tube;

DOI:10.1016/j.tetlet.2017.09.034

Reference yield: 96.0%

2-vinyloxybenzamide (88576-66-3) → 2-ethoxybenzamide (938-73-8)

Guidance literature:

With hydrogen; nickel; In ethanol; for 5h; under 29420.3 Torr;

DOI:10.1007/BF00955793

Reference yield: 88.0%

ethanol (64-17-5) + 2-Bromobenzamide (4001-73-4) → 2-ethoxybenzamide (938-73-8) + 2-[2-(ethyloxy)phenyl]quinazoline-4(3H)-one (64055-53-4)

Guidance literature:

With copper(l) iodide; caesium carbonate; at 119 - 120 ℃; under 7757.43 - 8274.59 Torr; Reagent/catalyst; Catalytic behavior; Microwave irradiation;

DOI:10.1002/ejoc.201800660

upstream raw materials:

methyl 2-ethoxybenzoate

2-ethoxybenzonitrile

ethyl iodide

salicylamide

Downstream raw materials:

2-(ethoxy)benzylamine

5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one

4-[(2-ethoxybenzoyl)amino]-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

C₉H₁₀⁽³⁾HNO₂

Refernces

• 1、 Kamble, Rohit B.,Mane, Kishor D.,Rupanawar, Bapurao D.,Korekar, Pranjal,Sudalai,Suryavanshi, Gurunath. "Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: Synthesis of primary amides". . p. 724 - 728. Retrieved 2020/01/23.
• 2、 Sayyad, Nisar,Cele, Zamani,Aleti, Rajeshwar Reddy,Bera, Milan,Cherukupalli, Srinivasulu,Chandrasekaran, Balakumar,Kushwaha, Narva Deshwar,Karpoormath, Rajshekhar. "Copper-Catalyzed Self-Condensation of Benzamide: Domino Reactions towards Quinazolinones". supporting information. p. 5382 - 5388. Retrieved 2018/10/20.