{(4R,5S,6S,7R,8R,9R)-8-[(3-acetylphenyl)amino]-9-amino-6,7-dihydroxy-4,6-dimethyl-2-oxo-3-oxa-1-azaspiro[4.4]non-7-yl}methyl 2-hydroxy-6-methylbenzoate

Base Information

Chemical Name:{(4R,5S,6S,7R,8R,9R)-8-[(3-acetylphenyl)amino]-9-amino-6,7-dihydroxy-4,6-dimethyl-2-oxo-3-oxa-1-azaspiro[4.4]non-7-yl}methyl 2-hydroxy-6-methylbenzoate
CAS No.:23754-55-4
Molecular Formula:C26H31 N3 O8
Molecular Weight:513.547
Hs Code.:
Mol file:23754-55-4.mol

{(4R,5S,6S,7R,8R,9R)-8-[(3-acetylphenyl)amino]-9-amino-6,7-dihydroxy-4,6-dimethyl-2-oxo-3-oxa-1-azaspiro[4.4]non-7-yl}methyl 2-hydroxy-6-methylbenzoate

Synonyms:2,6-Cresoticacid, a-ester with8-(m-acetylanilino)-9-amino-6,7-dihydroxy-7-(hydroxymethyl)-4,6-dimethyl-3-oxa-1-azaspiro[4.4]nonan-2-one,stereoisomer (8CI); Benzoic acid, 2-hydroxy-6-methyl-,[8-[(3-acetylphenyl)amino]-9-amino-6,7-dihydroxy-4,6-dimethyl-2-oxo-3-oxa-1-azaspiro[4.4]non-7-yl]methylester, [5R-[5a(S*),6b,7a,8b,9a]]-; 3-Oxa-1-azaspiro[4.4]nonane,benzoic acid deriv.; 2,6-Cresotic acid, monoester with8-(m-acetylanilino)-9-amino-6,7-dihydroxy-6-(hydroxymethyl)-4,7-dimethyl-3-oxa-1-azaspiro[4.4]nonan-2-one;Pactamycate

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Chemical Property of {(4R,5S,6S,7R,8R,9R)-8-[(3-acetylphenyl)amino]-9-amino-6,7-dihydroxy-4,6-dimethyl-2-oxo-3-oxa-1-azaspiro[4.4]non-7-yl}methyl 2-hydroxy-6-methylbenzoate

Chemical Property:

Vapor Pressure:5.93E-25mmHg at 25°C
Boiling Point:770.2°C at 760 mmHg
Flash Point:419.6°C
Density:1.44g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of {(4R,5S,6S,7R,8R,9R)-8-[(3-acetylphenyl)amino]-9-amino-6,7-dihydroxy-4,6-dimethyl-2-oxo-3-oxa-1-azaspiro[4.4]non-7-yl}methyl 2-hydroxy-6-methylbenzoate

There total 18 articles about {(4R,5S,6S,7R,8R,9R)-8-[(3-acetylphenyl)amino]-9-amino-6,7-dihydroxy-4,6-dimethyl-2-oxo-3-oxa-1-azaspiro[4.4]non-7-yl}methyl 2-hydroxy-6-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1295471-36-1
C₂₆H₂₉N₅O₈

: 23754-55-4
pactamycate

Guidance literature:: With ammonium chloride; zinc; In tetrahydrofuran; ethanol; water; at 20 ℃;
DOI:10.1021/jo301638z

Reference yield:

: 1403757-80-1
(1S,2R,3R,4S,5S)-4-azido-1-((tert-butyldiphenylsilyloxy)-methyl)-3-((S)-1-hydroxyethyl)-3-(4-methoxybenzylamino)-2-methyl-5-(3-(prop-1-en-2-yl)phenylamino)cyclopentane-1,2-diol

: 23754-55-4
pactamycate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyrographite; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide; water / acetone; tetrahydrofuran / 2 h / 20 °C

3.1: sodium periodate / water; tetrahydrofuran / 3 h / 20 °C

4.1: trifluoroacetic acid / neat (no solvent) / 40 °C

5.1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane; tetrahydrofuran / 20 °C

5.2: 20 °C

6.1: ammonium chloride; zinc / water; tetrahydrofuran; ethanol / 20 °C

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; water; pyrographite; ammonium chloride; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jo301638z

Reference yield:

: 1403757-81-2
(4S,5R,6R,7S,8S,9S)-9-azido-7-((tert-butyldiphenylsilyloxy)-methyl)-6,7-dihydroxy-1-(4-methoxybenzyl)-4,6-dimethyl-8-(3-(prop-1-en-2-yl)phenylamino)-3-oxa-1-azaspiro[4.4]nonan-2-one

: 23754-55-4
pactamycate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide; water / acetone; tetrahydrofuran / 2 h / 20 °C

2.1: sodium periodate / water; tetrahydrofuran / 3 h / 20 °C

3.1: trifluoroacetic acid / neat (no solvent) / 40 °C

4.1: pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane; tetrahydrofuran / 20 °C

4.2: 20 °C

5.1: ammonium chloride; zinc / water; tetrahydrofuran; ethanol / 20 °C

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; water; ammonium chloride; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jo301638z