compound 20

Base Information

Chemical Name:compound 20
CAS No.:74075-33-5
Molecular Formula:C24H26 N2 O5
Molecular Weight:422.481
Hs Code.:
Mol file:74075-33-5.mol

Synonyms:L-Proline,1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-, (S)-; Ketoace

Suppliers and Price of compound 20

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of compound 20

Chemical Property:

Vapor Pressure:1.12E-22mmHg at 25°C
Boiling Point:734.9°C at 760 mmHg
Flash Point:398.3°C
PSA：107.27000
Density:1.271g/cm³
LogP:2.96530

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of compound 20

There total 15 articles about compound 20 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 74075-32-4
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenyl-hexanoyl-L-proline benzyl ester

: 74075-33-5
SRI-20

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; for 48h; Product distribution / selectivity;

Reference yield:

: 74075-31-3,83356-17-6
(5S)-5-[(N-benzoyl)amino]-4-oxo-6-phenyl-hexanoic acid

: 74075-33-5
SRI-20

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / N-ethyl-N'-(dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole hydrate; diisopropylethylamine / dimethylformamide; CH₂Cl₂ / 50 h / 0 - 20 °C

2: 82 percent / H₂ / Pd/C / ethyl acetate; methanol / 48 h / 20 °C / 760 Torr

With hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.06.003

Reference yield:

: 33861-65-3
N-phthaloyl-L-phenylalanine-2-mercaptopyridyl thioester

: 74075-33-5
SRI-20

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) magnesium / 1.) THF, from 30 deg C to 35 deg C, 1 h, 2.) THF, RT, 20 h

2: 58 percent / p-toluenesulfonyl chloride / toluene / 11 h

3: 1.3 g / hydrazine / ethanol / 0.25 h / Heating

4: 72.9 percent / pyridine / 72 h / Ambient temperature

5: 59 percent / CrO₃, 35percent H₂SO₄ / acetone / 1 h / Ambient temperature

6: trifluoroacetic acid; H₂O / 16 h / Ambient temperature

7: 71 percent / 1-hydroxybenzotriazole hydrate, triethylamine, dicyclohexylcarbodiimide / CH₂Cl₂ / 72 h / Ambient temperature

8: 71.8 percent / H₂ / 10percent Pd/C / acetic acid / 15 h / 760 Torr

With chromium(VI) oxide; sulfuric acid; hydrogen; magnesium; 1-hydroxybenzotriazol-hydrate; triethylamine; p-toluenesulfonyl chloride; dicyclohexyl-carbodiimide; hydrazine; palladium on activated charcoal; In pyridine; ethanol; dichloromethane; water; acetic acid; acetone; toluene; trifluoroacetic acid;
DOI:10.1021/jm00186a020