Benzamide, 5-amino-N-(2-(cyclopropylmethylamino)ethyl)-4-fluoro-2-methoxy-

Base Information

Chemical Name:Benzamide, 5-amino-N-(2-(cyclopropylmethylamino)ethyl)-4-fluoro-2-methoxy-
CAS No.:151793-16-7
Molecular Formula:C₁₄H₂₀FN₃O₂
Molecular Weight:281.33
Hs Code.:
DSSTox Substance ID:DTXSID80164871
Nikkaji Number:J551.078C
Wikidata:Q83033961

Synonyms:5-Amino-N-(2-(cyclopropylmethylamino)ethyl)-4-fluoro-2-methoxybenzamide;Benzamide, 5-amino-N-(2-(cyclopropylmethylamino)ethyl)-4-fluoro-2-methoxy-;151793-16-7;DTXSID80164871;LS-25479;N-[2-(Cyclopropyl(methyl)amino)ethyl]-2-methoxy-4-fluoro-5-aminobenzamide

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzamide, 5-amino-N-(2-(cyclopropylmethylamino)ethyl)-4-fluoro-2-methoxy-

Chemical Property:

Vapor Pressure:1.05E-06mmHg at 25°C
Boiling Point:403°C at 760 mmHg
Flash Point:197.5°C
Density:1.23g/cm³
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:281.15395505
Heavy Atom Count:20
Complexity:338

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(CCNC(=O)C1=CC(=C(C=C1OC)F)N)C2CC2

Technology Process of Benzamide, 5-amino-N-(2-(cyclopropylmethylamino)ethyl)-4-fluoro-2-methoxy-

There total 9 articles about Benzamide, 5-amino-N-(2-(cyclopropylmethylamino)ethyl)-4-fluoro-2-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91907-31-2
N-benzyl-N-cyclopropylethylenediamine

: 151793-16-7
5-Amino-N-[2-(cyclopropyl-methyl-amino)-ethyl]-4-fluoro-2-methoxy-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / 0.5 h / 50 - 70 °C

2: 100 percent / H₂, HCl / 5percent Pd/C / ethanol / 2 h / Ambient temperature

3: 91 percent / potassium carbonate / dimethylformamide / 0.25 h / 80 °C

4: 88 percent / 15percent aq. HCl / 2 h / Heating

5: tetrahydrofuran / 1 h / 50 °C

With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(93)90129-3

Reference yield:

: 204707-42-6
methyl 4-fluoro-2-methoxybenzoate

: 151793-16-7
5-Amino-N-[2-(cyclopropyl-methyl-amino)-ethyl]-4-fluoro-2-methoxy-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / HNO₃, conc. H₂SO₄ / 0.17 h / -5 °C

2: 95 percent / H₂ / Ni-Raney / ethanol / 2 h / 60 °C

3: 68 percent / 2N aq. NaOH / Heating

4: tetrahydrofuran / 30 °C

5: tetrahydrofuran / 1 h / 50 °C

With sodium hydroxide; sulfuric acid; hydrogen; nitric acid; Ni-Raney; In tetrahydrofuran; ethanol;
DOI:10.1016/0223-5234(93)90129-3

Reference yield:

: 126105-21-3
N-acetyl-N'benzyl-N'-cyclopropylethylenediamine

: 151793-16-7
5-Amino-N-[2-(cyclopropyl-methyl-amino)-ethyl]-4-fluoro-2-methoxy-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂, HCl / 5percent Pd/C / ethanol / 2 h / Ambient temperature

2: 91 percent / potassium carbonate / dimethylformamide / 0.25 h / 80 °C

3: 88 percent / 15percent aq. HCl / 2 h / Heating

4: tetrahydrofuran / 1 h / 50 °C

With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(93)90129-3