11,18:18,21-Diepoxypregn-4-ene-3,20-dione

Base Information

Chemical Name:11,18:18,21-Diepoxypregn-4-ene-3,20-dione
CAS No.:93177-03-8
Molecular Formula:C₂₁H₂₆O₄
Molecular Weight:342.435
Hs Code.:
DSSTox Substance ID:DTXSID30918629
Mol file:93177-03-8.mol

Synonyms:11,18-18,21-diepoxypregn-4-ene-3,20-dione;18,21-anhydroaldosterone

Suppliers and Price of 11,18:18,21-Diepoxypregn-4-ene-3,20-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 11,18:18,21-Diepoxypregn-4-ene-3,20-dione

Chemical Property:

Vapor Pressure:3.55E-11mmHg at 25°C
Boiling Point:526.5°C at 760 mmHg
Flash Point:232.3°C
PSA：52.60000
Density:1.29g/cm³
LogP:3.04870
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:342.18310931
Heavy Atom Count:25
Complexity:711

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CCC(=O)C=C1CCC3C2C4CC56C3CCC5C(=O)COC6O4
Isomeric SMILES:C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@@H]4CC56[C@H]3CC[C@@H]5C(=O)COC6O4

Technology Process of 11,18:18,21-Diepoxypregn-4-ene-3,20-dione

There total 11 articles about 11,18:18,21-Diepoxypregn-4-ene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

: 6251-69-0
aldosterone

: 93177-03-8
18,21-Anhydroaldosterone

Guidance literature:: With hydrogenchloride; In ethanol; water; at 20 ℃; for 0.5h;
DOI:10.1248/cpb.56.873

Reference yield: 60.0%

: 2827-21-6
aldosterone 21-acetate

: 150607-96-8
(2S,3S,4S,5R,6R)-2-(methoxycarbonyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl tris(2-methylpropanoate)

: triisobutyrylaldosterone-18α-glucuronide

: 93177-03-8
18,21-Anhydroaldosterone

Guidance literature:: (2S,3S,4S,5R,6R)-2-(methoxycarbonyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl tris(2-methylpropanoate); With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -10 ℃; for 0.0833333h; Molecular sieve; Inert atmosphere;

aldosterone 21-acetate; In dichloromethane; for 24h; Inert atmosphere; Molecular sieve;
DOI:10.1002/chem.202004154

Reference yield: 50.0%

: 2827-21-6
aldosterone 21-acetate

: 150607-96-8
(2S,3S,4S,5R,6R)-2-(methoxycarbonyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl tris(2-methylpropanoate)

: triisobutyrylaldosterone-18α-glucuronide

: triisobutyrylaldosterone-18-2'O-glucuronide

: 93177-03-8
18,21-Anhydroaldosterone

Guidance literature:: (2S,3S,4S,5R,6R)-2-(methoxycarbonyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl tris(2-methylpropanoate); With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -10 ℃; for 0.0833333h; Molecular sieve; Inert atmosphere;

aldosterone 21-acetate; In dichloromethane; for 24h; Molecular sieve; Inert atmosphere;
DOI:10.1002/chem.202004154