18,21-Dihydroxy-11,18-epoxypregn-4-ene-3,20-dione

Base Information

Chemical Name:18,21-Dihydroxy-11,18-epoxypregn-4-ene-3,20-dione
CAS No.:6251-69-0
Molecular Formula:C21H28O5
Molecular Weight:360.45
Hs Code.:
DSSTox Substance ID:DTXSID70978106
Nikkaji Number:J925.564H
Mol file:6251-69-0.mol

Synonyms:BIDD:PXR0100;DTXSID70978106;18,21-Dihydroxy-11,18-epoxypregn-4-ene-3,20-dione

Suppliers and Price of 18,21-Dihydroxy-11,18-epoxypregn-4-ene-3,20-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 18,21-Dihydroxy-11,18-epoxypregn-4-ene-3,20-dione

Chemical Property:

Vapor Pressure:6.23E-16mmHg at 25°C
Boiling Point:581.3°C at 760 mmHg
Flash Point:206.8°C
PSA：83.83000
Density:1.32g/cm³
LogP:2.00310
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:360.19367399
Heavy Atom Count:26
Complexity:699

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s): A reproductive hazard.
Hazard Codes:A reproductive hazard.

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CCC(=O)C=C1CCC3C2C4CC5(C3CCC5C(=O)CO)C(O4)O
Isomeric SMILES:C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@@H]4C[C@]5([C@H]3CC[C@@H]5C(=O)CO)[C@H](O4)O

Technology Process of 18,21-Dihydroxy-11,18-epoxypregn-4-ene-3,20-dione

There total 4 articles about 18,21-Dihydroxy-11,18-epoxypregn-4-ene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-85-7
21-Hydroxyprogesterone

: 6251-69-0
aldosterone

: 50-22-6
Corticosterone

: 3885-55-0
11β,18,21-trihydroxy-4-pregnen-3,20-dione

Guidance literature:: With carbon dioxide; adenomatous adrenal tissue of patients with primary aldosteronism; Krebs-Ringer bicarbonate solution; oxygen; In ethanol; at 37 ℃; for 1h; Product distribution; tritium labeled study;
DOI:10.1016/0039-128X(80)90076-8

Reference yield:

: 57-83-0
Progesterone

: 6251-69-0
aldosterone

: 64-85-7
21-Hydroxyprogesterone

: 50-22-6
Corticosterone

: 3885-55-0
11β,18,21-trihydroxy-4-pregnen-3,20-dione

Guidance literature:: With carbon dioxide; adenomatous adrenal tissue of patients with primary aldosteronism; Krebs-Ringer bicarbonate solution; oxygen; In ethanol; at 37 ℃; for 1h; Product distribution; tritium labeled study;
DOI:10.1016/0039-128X(80)90076-8

Reference yield:

: 64-85-7
21-Hydroxyprogesterone

: 6251-69-0
aldosterone

: 50-22-6
Corticosterone

: 379-68-0
18-Hydroxydeoxycorticosterone

Guidance literature:: With Krebs-Ringer-bicarbonate-glucose buffer; male CHBB-Thom rat adrenal mitochondria; NADPH; Kinetics; partial inhib. by cortisol;
DOI:10.1016/0039-128X(94)00064-J