N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride

Base Information

Chemical Name:N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
CAS No.:170449-18-0
Molecular Formula:C₁₆H₁₄ClN₃O₂*ClH
Molecular Weight:352.22
Hs Code.:2933990090
UNII:QP952C4RUW
DSSTox Substance ID:DTXSID4057891
Pharos Ligand ID:7MLQLSP8RPNS
ChEMBL ID:CHEMBL540068
Mol file:170449-18-0.mol

Synonyms:4-(3-chloroanilino)-6,7-dimethoxyquinazoline;AG 1478;AG-1478;AG1478;RTKI cpd;tyrphostin AG 1478;tyrphostin AG 1478 monohydrochloride;tyrphostin AG 1478-mesylate;tyrphostin-AG1478

Suppliers and Price of N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AG1478Hydrochloride
10mg
$ 110.00

Crysdot
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-aminehydrochloride 95+%
1g
$ 551.00

Crysdot
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-aminehydrochloride 95+%
250mg
$ 220.00

Chemenu
N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-aminehydrochloride 95%
1g
$ 520.00

Biosynth Carbosynth
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
25 mg
$ 325.00

Biosynth Carbosynth
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
10 mg
$ 285.00

Biosynth Carbosynth
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
250 mg
$ 480.00

Biosynth Carbosynth
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
100 mg
$ 430.00

Biosynth Carbosynth
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
50 mg
$ 380.00

Alichem
N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-aminehydrochloride
5g
$ 1965.46

Total 25 raw suppliers

Chemical Property of N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride

Chemical Property:

Vapor Pressure:1.37E-08mmHg at 25°C
Melting Point:230-235 °C
Boiling Point:458.5 °C at 760mmHg
Flash Point:231.1 °C
PSA：56.27000
Density:1.337 g/cm³
LogP:4.91900
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:351.0541321
Heavy Atom Count:23
Complexity:360

Purity/Quality:

99%, ^*data from raw suppliers

AG1478Hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC.Cl

Technology Process of N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride

There total 6 articles about N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 108-42-9
3-chloro-aniline

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 170449-18-0
Tyrphostin hydrochloride

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1021/jm050607w

Reference yield: 72.0%

: 170449-18-0
Tyrphostin hydrochloride

Guidance literature:

Reference yield:

: 13794-72-4
3H-6,7-dimethoxyquinazolin-4-one

: 170449-18-0
Tyrphostin hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / oxalyl chloride; DMF / 1,2-dichloro-ethane / 2.5 h / Heating

2: 90 percent / dimethylformamide / 80 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050607w