1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-phenyl-1-piperazinyl)propyl)-

Base Information

Chemical Name:1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-phenyl-1-piperazinyl)propyl)-
CAS No.:124556-76-9
Molecular Formula:C₂₂H₂₃ClN₆O
Molecular Weight:422.917
Hs Code.:
DSSTox Substance ID:DTXSID60154432
Wikidata:Q83021671

Synonyms:1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-phenyl-1-piperazinyl)propyl)-;8-Chloro-2-(3-(4-phenyl-1-piperazinyl)propyl)-1,2,4-triazolo(3,4-a)phthalazin-3(2H)-one;124556-76-9;DTXSID60154432;LS-156624

Suppliers and Price of 1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-phenyl-1-piperazinyl)propyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-phenyl-1-piperazinyl)propyl)-

Chemical Property:

Vapor Pressure:3.18E-14mmHg at 25°C
Boiling Point:597.1°C at 760 mmHg
Flash Point:314.9°C
Density:1.39g/cm³
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:422.1621871
Heavy Atom Count:30
Complexity:685

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1CCCN2C(=O)N3C(=N2)C4=C(C=C(C=C4)Cl)C=N3)C5=CC=CC=C5

Technology Process of 1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-phenyl-1-piperazinyl)propyl)-

There total 4 articles about 1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-phenyl-1-piperazinyl)propyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 10599-17-4
1-(3-chloropropyl)-4-phenylpiperazine

: 124556-79-2
8-chloro-1,2,4-triazolo<3,4-a>phthalazin-3(2H)-one

: 124556-76-9
8-Chloro-2-[3-(4-phenyl-piperazin-1-yl)-propyl]-2H-[1,2,4]triazolo[3,4-a]phthalazin-3-one

Guidance literature:: With sodium hydroxide; mineral oil; In N,N-dimethyl-formamide; at 80 ℃; for 25h; 1.) 60 deg C, 2 h;

Reference yield:

: 57835-96-8
6-chlorophthalazine-1(2H)-one

: 124556-76-9
8-Chloro-2-[3-(4-phenyl-piperazin-1-yl)-propyl]-2H-[1,2,4]triazolo[3,4-a]phthalazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / phosphorus oxychloride / 0.33 h / 100 °C

2: 91 percent / hydrazine hydrate / ethanol / 1 h / Heating

3: 80 percent / 1 h / 330 - 350 °C

4: 49 percent / 1.) NaOH/mineral oil / dimethylformamide / 25 h / 80 °C / 1.) 60 deg C, 2 h

With sodium hydroxide; hydrazine hydrate; mineral oil; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 124556-78-1
1,6-dichlorophthalazine

: 124556-76-9
8-Chloro-2-[3-(4-phenyl-piperazin-1-yl)-propyl]-2H-[1,2,4]triazolo[3,4-a]phthalazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / hydrazine hydrate / ethanol / 1 h / Heating

2: 80 percent / 1 h / 330 - 350 °C

3: 49 percent / 1.) NaOH/mineral oil / dimethylformamide / 25 h / 80 °C / 1.) 60 deg C, 2 h

With sodium hydroxide; hydrazine hydrate; mineral oil; In ethanol; N,N-dimethyl-formamide;