Piperazine, 1-(3-chloropropyl)-4-phenyl-

Base Information

• Chemical Name: Piperazine, 1-(3-chloropropyl)-4-phenyl-
• CAS No.: 10599-17-4
• Molecular Formula: C13H19 Cl N2
• Molecular Weight: 238.76
• DSSTox Substance ID: DTXSID10147455
• Nikkaji Number: J1.184.670J
• Wikidata: Q83012766

Synonyms:1-(3-chloropropyl)-4-phenylpiperazine;Piperazine, 1-(3-chloropropyl)-4-phenyl-;10599-17-4;Piperazine, 1-(3-chloropropyl)-4-phenyl-,;SCHEMBL6637417;DTXSID10147455;AQLHJNRNLYDLDP-UHFFFAOYSA-N;AKOS010538970;4-phenyl-1-(3-chloropropyl)piperazine;1-chloro-3-(4-phenylpiperazinyl)propane;3-(4-phenyl-piperazino)-propyl chloride;3-(4-phenylpiperazin-1-yl)propylchloride;3-(4-phenylpiperazin-1yl)propyl chloride;1-(gamma-chloropropyl)-4-phenylpiperazine;3-(4-phenylpiperazin-1-yl)propyl chloride;CS-0300152;EN300-208588

Chemical Property of Piperazine, 1-(3-chloropropyl)-4-phenyl-

Chemical Property:

• Vapor Pressure: 3.32E-05mmHg at 25°C
• Boiling Point: 354.5°Cat760mmHg
• Flash Point: 168.2°C
• Density: 1.094g/cm³
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 238.1236763
• Heavy Atom Count: 16
• Complexity: 184

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CCCCl)C2=CC=CC=C2

Technology Process of Piperazine, 1-(3-chloropropyl)-4-phenyl-

There total 8 articles about Piperazine, 1-(3-chloropropyl)-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

4-phenyl-1-piperazine (92-54-6) + 1.3-chlorobromopropane (109-70-6) → 1-(3-chloropropyl)-4-phenylpiperazine (10599-17-4)

Guidance literature:

With potassium carbonate; In acetone; at 0 - 20 ℃; for 0.48h;

DOI:10.1016/j.ejmech.2020.112435

Reference yield: 74.0%

1-phenyl-4-(3-hydroxypropyl)piperazine (67514-07-2) → 1-(3-chloropropyl)-4-phenylpiperazine (10599-17-4)

Guidance literature:

With triphenylphosphine; In tetrachloromethane; Heating;

DOI:10.1248/cpb.35.2394

Reference yield: 71.0%

1-phenyl-4-(3-hydroxypropyl)piperazine (67514-07-2) + p-toluenesulfonyl chloride (98-59-9) → 1-(3-chloropropyl)-4-phenylpiperazine (10599-17-4)

Guidance literature:

With triethylamine; In dichloromethane;

upstream raw materials:

4-phenyl-1-piperazine

1.3-chlorobromopropane

1-phenyl-4-(3-hydroxypropyl)piperazine

p-toluenesulfonyl chloride

Downstream raw materials:

1-phenyl-4-(3-piperidino-propyl)-piperazine

4-[3-(4-phenyl-piperazino)-propyl]-morpholine

1-(3-diethylamino-propyl)-4-phenyl-piperazine

1-(4-phenyl-piperazino)-3-(4-p-tolyl-piperazino)-propane

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