N-Benzyl-2-benzylaminopropanamide

Base Information

• Chemical Name: N-Benzyl-2-benzylaminopropanamide
• CAS No.: 142713-67-5
• Molecular Formula: C17H20 N2 O
• Molecular Weight: 268.3535
• DSSTox Substance ID: DTXSID70931610
• Nikkaji Number: J3.026.728A
• Mol file: 142713-67-5.mol

Synonyms:N-Benzyl-2-benzylaminopropanamide;142713-67-5;CCRIS 5673;N-benzyl-2-(benzylamino)propanamide;DTXSID70931610;N-Benzyl-2-(benzylamino)propanimidic acid

Chemical Property of N-Benzyl-2-benzylaminopropanamide

Chemical Property:

• Vapor Pressure: 6.04E-09mmHg at 25°C
• Boiling Point: 468.3°C at 760 mmHg
• Flash Point: 172°C
• Density: 1.083g/cm³
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 268.157563266
• Heavy Atom Count: 20
• Complexity: 281

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)NCC1=CC=CC=C1)NCC2=CC=CC=C2

Technology Process of N-Benzyl-2-benzylaminopropanamide

There total 3 articles about N-Benzyl-2-benzylaminopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-(benzylamino)-1-oxopropan-2-yl methanesulfonate (1360567-09-4) + benzylamine (100-46-9) → N-benzyl-2-(phenoxy)propanamide (142713-67-5)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃; for 48h;

DOI:10.1002/anie.201105164

Reference yield:

N-(Phenylmethyl)-2-hydroxypropanamide (6295-31-4) → N-benzyl-2-(phenoxy)propanamide (142713-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 5 - 20 °C

2: potassium carbonate / acetonitrile / 48 h / 60 °C

With potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1002/anie.201105164

Reference yield:

(R)-N-Benzyl-2-bromo-propionamide (131432-91-2) + benzylamine (100-46-9) → N-benzyl-2-(phenoxy)propanamide (142713-67-5)

Guidance literature:

In toluene; for 2h; Heating;

DOI:10.1016/S0957-4166(00)82368-X

upstream raw materials:

(R)-N-Benzyl-2-bromo-propionamide

benzylamine

N-(Phenylmethyl)-2-hydroxypropanamide

1-(benzylamino)-1-oxopropan-2-yl methanesulfonate