6295-31-4

Upstream product

• 97-64-3 ethyl 2-hydroxypropionate 
• 100-46-9 benzylamine 
• 547-64-8 methyl lactate 
• 6653-71-0 N-benzyl-2-bromopropanamide 
• 95-96-5 D,L-lactide 
• 57-55-6 propylene glycol 

Downstream Products

• 1360567-09-4 1-(benzylamino)-1-oxopropan-2-yl methanesulfonate 
• 142713-67-5 N-benzyl-2-(phenoxy)propanamide 
• 124371-71-7 N?benzyl?2?phenoxypropanamide 
• 1360567-16-3 N-benzyl-2-(ethylthio)propanamide 
• 1309658-34-1 2-azido-N-benzylpropanamide 
• 109017-91-6 N-(benzyl)-4,5-dimethyl-4-oxazolin-2-one 

Relevant academic research and scientific papers

Metal-ligand cooperation in the catalytic dehydrogenative coupling (DHC) of polyalcohols to carboxylic acid derivatives

Several polyols, which are easily available from sugars through biochemical conversion or hydrogenolytic cleavage, are directly converted into carboxylic acids and amides. This efficient dehydrogenative coupling process, catalyzed by a rhodium(I) diolefin amido complex, is an attractive approach for the production of organic fine chemicals from renewable resources. This method tolerates the presence of several hydroxy groups and can be extended to the direct synthesis of lactams from the corresponding amino alcohols under mild conditions.

FORUMLATIONS

This invention relates to the use of lactamide compounds of formula (I): CH3CH(OH)C(=O)NR1R2, where R1 and R2 are each independently hydrogen; or C1-6 alkyl, C2-6 alkenyl or C3-6 cycloalkyl, each of which is optionally substituted by up to three substituents independently selected from phenyl, hydroxy, C1-5 alkoxy, morpholinyl and NR3R4 where R3 and R4 are each independently C1-3 alkyl; or phenyl optionally substituted by up to three substituents independently selected from C1-3 alkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a morpholinyl, pyrrolidinyl, piperidinyl or azepanyl ring, each of which is optionally substituted by up to three substituents independently selected from C1-3 alkyl, in formulations to reduce the toxicity associated with other formulation components; to the use of certain lactamide compounds as solvents, especially in formulations, particularly in agrochemical formulations and in environmentally friendly formulations; to novel lactamide compounds; and to processes for preparing lactamide compounds.

Acyl transfer catalysis with 1,2,4-Triazole anion

1,2,4-Triazole anion has been identified as an active acyl transfer catalyst suitable for the aminolysis and transesterification of esters.

Inexpensive Reagents for the Synthesis of Amides from Esters and for Regioselective Opening of Epoxides

Lithium aluminum amides , 6a-6d, easily prepared in Et2O or THF from 1 equiv of LiAlH4 and 5 equiv of amine, proved to be efficient reagents for the synthesis of secondary amides from esters (ca. 100 percent with unhindered amines and 92 percent with t-BuNH2).They also open aryl epoxides with very high regioselectivity to give 97-98 percent of the β-amino-α-arylethanols (corresponding to the SN2 mechanism).

BASE-PROMOTED CYCLOCOUPLING REACTION OF 2-BROMOPROPANAMIDES AND 2-BROMOACETAMIDES WITH DMF

In the presence of a suitable base, representative 2-bromopropanamides 4 and 2-bromoacetamides 5 undergo cyclocondensation onto the carbonyl group of DMF to yield the 2-(dimethylamino)oxazolidin-4-ones 6 and 10, respectively.Of these cyclic orthoester ami