4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXO-

Base Information

• Chemical Name: 4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXO-
• CAS No.: 84378-44-9
• Molecular Formula: C13H10 F N3 O3
• Molecular Weight: 275.24
• Hs Code.: 2933998090
• Mol file: 84378-44-9.mol

Synonyms:Flumazenilacid; Ro 15-3890

Chemical Property of 4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXO-

Chemical Property:

• Vapor Pressure: 7.46E-14mmHg at 25°C
• Boiling Point: 570.5°C at 760 mmHg
• Flash Point: 298.8°C
• PSA: 75.43000
• Density: 1.55g/cm³
• LogP: 1.23310
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98%,99%, ^*data from raw suppliers

FlumazenilCarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Flumazenil carboxylic acid is a derivative of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.

Technology Process of 4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXO-

There total 3 articles about 4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID, 8-FLUORO-5,6-DIHYDRO-5-METHYL-6-OXO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

flumazenil (78755-81-4) → 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid (84378-44-9)

Guidance literature:

flumazenil; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃;

With hydrogenchloride; In water;

DOI:10.1016/j.bmcl.2012.11.066

Reference yield: 97.0%

→ 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid (84378-44-9)

Guidance literature:

Reference yield: 40.0%

→ 2-[[(1,1-dimethylethoxy)carbonyl]amino]propyl Ester + 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid (84378-44-9)

Guidance literature:

upstream raw materials:

flumazenil

Downstream raw materials:

C₁₆H₁₅F₂N₃O₃

8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid 3-[{2-[tert-butoxycarbonyl-(2-tritylsulfanyl-ethyl)-amino]-ethyl}-(2-tritylsulfanyl-ethyl)-amino]-propyl ester

2-[(p-toluenesulfonyl)oxy]ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

[18F]FFMZ

Refernces

• 1、 Jeong,Hong,Lee,Chung,Lee,Cho,Oh,Lee. "Synthesis of no-carrier-added [18F]fluoroflumazenil". . p. S517-S519. Retrieved 2007/10/03.