Chemical Property of Flumazenil
Chemical Property:
- Appearance/Colour:Colourless crystals
- Vapor Pressure:3.1E-11mmHg at 25°C
- Melting Point:201-203 °C
- Refractive Index:1.633
- Boiling Point:528 °C at 760 mmHg
- PKA:0.86±0.20(Predicted)
- Flash Point:273.1 °C
- PSA：64.43000
- Density:1.39 g/cm3
- LogP:1.71160
- Storage Temp.:2-8°C
- Solubility.:Soluble in DMSO to 25mM
- Water Solubility.:128 mg/L
- XLogP3:1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:3
- Exact Mass:303.10191948
- Heavy Atom Count:22
- Complexity:461
- Purity/Quality:
-
99%, *data from raw suppliers
Flumazenil
*data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-27-36/37/39
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C
- Recent ClinicalTrials:Reversal of Remimazolam by a Single Dose of Flumazenil
- Recent EU Clinical Trials:Cognitive impairment and functional reorganization in multiple sclerosis: The role of GABA and glutamate
- Recent NIPH Clinical Trials:Comparison of remimazolam + flumazenil antagonization and propofol on emergence time in patients who undergo awake craniotomy: a randomized comparative study
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Description
Flumazenil is a benzodiazepine antagonist useful as a fast-acting antidote in the treatment
of benzodiazepine intoxication, and in reversing the central sedative effects of
benzodiazepines during anesthesia.
-
Uses
Flumazenil is an imidazodiazepine which selectively blocks the central effects of classic benzodiazepines. It is used as benzodiazepine antagonist sedation reversal drug.
-
Therapeutic Function
Benzodiazepine receptor antagonist, Anticonvulsant
-
Clinical Use
Reversal of sedative effects of benzodiazepines in
anaesthetic, intensive care, and diagnostic procedures
-
Drug interactions
Potentially hazardous interactions with other drugs
None known
