3-Morpholino-1,2-propanediol

Base Information

• Chemical Name: 3-Morpholino-1,2-propanediol
• CAS No.: 6425-32-7
• Molecular Formula: C7H15NO3
• Molecular Weight: 161.201
• Hs Code.: 2934999090
• European Community (EC) Number: 229-193-1
• DSSTox Substance ID: DTXSID40982795
• Nikkaji Number: J207.040E
• Mol file: 6425-32-7.mol

Synonyms:3-Morpholino-1,2-propanediol;6425-32-7;3-Morpholinopropane-1,2-diol;3-morpholin-4-ylpropane-1,2-diol;3-(morpholin-4-yl)propane-1,2-diol;EINECS 229-193-1;SCHEMBL11186;3-morpholino propylene glycol;DTXSID40982795;3-(n-morpholino)-1,2-propanediol;3-morpholin-4-yl-propane-1,2-diol;BBL027564;MFCD00006176;STL373548;AKOS005207318;1,2-Propanediol, 3-(4-morpholinyl)-;3-(4-Morpholinyl)-1,2-propanediol #;3-Morpholino-1,2-propanediol, >=96%;AS-59458;3-(4-Morpholinyl)-1,2-propanediol, 97%;FT-0613693;M0934;D91406

Chemical Property of 3-Morpholino-1,2-propanediol

Chemical Property:

• Vapor Pressure: 0.000232mmHg at 25°C
• Melting Point: 37-38 °C(lit.)
• Refractive Index: n20/D 1.493
• Boiling Point: 290.1 °C at 760 mmHg
• Flash Point: 136.9 °C
• PSA: 52.93000
• Density: 1.167 g/cm³
• LogP: -1.39030
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 161.10519334
• Heavy Atom Count: 11
• Complexity: 104

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Morpholino-1,2-propanediol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CC(CO)O

Technology Process of 3-Morpholino-1,2-propanediol

There total 5 articles about 3-Morpholino-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

morpholine (110-91-8,99108-56-2) + oxiranyl-methanol (556-52-5) → 3-morpholin-4-yl-propane-1,2-diol (6425-32-7)

Guidance literature:

at 20 ℃; for 2h; Solvent; Time;

DOI:10.1021/ol500518n

Reference yield:

morpholine (110-91-8,99108-56-2) + 1-bromo-2,3-propanediol (4704-77-2) → 3-morpholin-4-yl-propane-1,2-diol (6425-32-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 - 75 ℃;

Reference yield:

morpholine (110-91-8,99108-56-2) + (R)-oxiranemethanol (57044-25-4) → 3-morpholin-4-yl-propane-1,2-diol (6425-32-7) + propanediol (598-44-7)

Guidance literature:

In methanol;

upstream raw materials:

4-(oxiran-2-ylmethyl)morpholine

morpholine

(R)-oxiranemethanol

oxiranyl-methanol

Downstream raw materials:

3-Hydroxy-3-methyl-2-butanone

4‐(morpholinomethyl)‐1,3‐dioxolan‐2‐one

3-morpholinopropane-1,2-diyl dibenzoate

4-[2,3-Bis-(2-nitro-4-trifluoromethanesulfonyl-phenoxy)-propyl]-morpholine

Refernces

• 1、 Sela, Tal,Vigalok, Arkadi. "Organic synthesis "on Water" vs "on Liquids": A comparative analysis". supporting information. p. 1964 - 1967. Retrieved 2014/05/06.
• 2、 Chezlov, I. G.,Zavlin, P. M.,Kuznetsov, L. L.. "Structure and Reactivity of Oxirane Chemical Modifiers for Gelatin". . p. 155 - 161. Retrieved 2007/10/03.