COCHLIOQUINONE A

Base Information

• Chemical Name: COCHLIOQUINONE A
• CAS No.: 32450-25-2
• Molecular Formula: C₃₀H₄₄O₈
• Molecular Weight: 532.675
• Hs Code.: 2933399990
• Mol file: 32450-25-2.mol

Synonyms:CochlioquinoneA; Pyrano[3,2-a]xanthene-8,11-dione, 1,2,3,4aa,5,6,6a,12,12aa,12b-decahydro-12a-hydroxy-9-(2-hydroxy-1,3-dimethylpentyl)-3b-(1-hydroxy-1-methylethyl)-6ab,12bb-dimethyl-, 9-acetate, stereoisomer (8CI);Cochiloquinone A; Luteoleersin; [3R-[3a,4ab,6aa,9(1S*,2R*,3S*),12b,12ab,12ba]]-9-[2-(Acetyloxy)-1,3-dimethylpentyl]-1,2,3,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-3-(1-hydroxy-1-methylethyl)-6a,12b-dimethylpyrano[3,2-a]xanthene-8,11-dione

Chemical Property of COCHLIOQUINONE A

Chemical Property:

• Appearance/Colour: Yellow solid.
• Vapor Pressure: 5.21E-19mmHg at 25°C
• Melting Point: 135 °C
• Boiling Point: 638.8 °C at 760 mmHg
• PKA: 11.57±0.70(Predicted)
• Flash Point: 200.1 °C
• PSA: 119.36000
• Density: 1.21 g/cm³
• LogP: 3.81720

Purity/Quality:

98%Min ^*data from raw suppliers

CochlioquinoneA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. Cochlioquinone A has recently been shown to be an antagonist of the human chemokine receptor, CCR5, in HIV-1,). Cochlioquinone A is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH-ubiquinone reductase. Cochlioquinone A, a bioactive compound isolated from D. sacchari and Bipolaris sp., is an inhibitor of diacylglycerol kinase (DGK; Ki = 3.1 μM) and diacylglycerol acyltransferase (DGAT; IC50 = 5.6 μM). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma with an IC50 value of 3 μM. It is also reported to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors with an IC50 value of 11 μM.[Cayman Chemical] Cochlioquinone A is an antagonist of CCR5. Diacylglycerol kinase inhibitor.

Technology Process of COCHLIOQUINONE A

There total 4 articles about COCHLIOQUINONE A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Cochliochinon A (32450-25-2,147384-57-4)

Guidance literature:

aus Luteoleersin durch Kristallisation;

Reference yield:

cochliohydroquinone-A (41059-86-3) → cochlioquinone A (32450-25-2)

Guidance literature:

With ethanol; water; iron(III) chloride;

Reference yield:

ethanol (64-17-5) + cochliohydroquinone-A (41059-86-3) → cochlioquinone A (32450-25-2)

Guidance literature:

upstream raw materials:

cochliohydroquinone-A

ethanol

Downstream raw materials:

cochliohydroquinone-A