4,4-Diphenylbutylamine

Base Information

• Chemical Name: 4,4-Diphenylbutylamine
• CAS No.: 36765-74-9
• Molecular Formula: C16H19 N
• Molecular Weight: 225.334
• Hs Code.: 2921499090
• European Community (EC) Number: 253-194-6
• DSSTox Substance ID: DTXSID10190229
• Nikkaji Number: J332.348J
• Wikidata: Q83062546
• ChEMBL ID: CHEMBL593734
• Mol file: 36765-74-9.mol

Synonyms:4,4-Diphenylbutylamine;36765-74-9;EINECS 253-194-6;4,4-Diphenylbutan-1-amine;diphenylbutylamine;D04SCQ;delta-Phenylbenzenebutanamine;SCHEMBL157808;CHEMBL593734;BDBM35935;DTXSID10190229;MAAQGZFMFXQVOG-UHFFFAOYSA-N;PD157826

Chemical Property of 4,4-Diphenylbutylamine

Chemical Property:

• Vapor Pressure: 1.48E-05mmHg at 25°C
• Boiling Point: 366.3°Cat760mmHg
• Flash Point: 174.1°C
• PSA: 26.02000
• Density: 1.011g/cm³
• LogP: 4.25770
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 225.151749610
• Heavy Atom Count: 17
• Complexity: 172

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CCCN)C2=CC=CC=C2

Technology Process of 4,4-Diphenylbutylamine

There total 13 articles about 4,4-Diphenylbutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4,4-diphenylbut-3-en-1-ylamine (93007-58-0) → 4,4-Diphenylbutylamine (36765-74-9)

Guidance literature:

With palladium 10% on activated carbon; at 20 ℃; for 8h;

DOI:10.1016/j.bmc.2013.06.038

Reference yield:

3,3-diphenylpropionitrile (22156-48-5) → 4,4-Diphenylbutylamine (36765-74-9)

Guidance literature:

With borane-THF; Inert atmosphere;

DOI:10.1016/j.bmc.2009.08.016

Reference yield:

4,4-diphenyl-1-butyl azide (182317-59-5) → 4,4-Diphenylbutylamine (36765-74-9)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; water; for 1.5h; under 2280 Torr;

DOI:10.1016/j.bmc.2004.10.029

upstream raw materials:

4,4-diphenyl-1-butyl azide

bromobenzene

4-hydroxy-4,4-diphenylbutyl chloride

4,4-Diphenyl-1-butyliodide

Downstream raw materials:

(2S,3S)-3-(4,4-Diphenyl-butylamino)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol

2-chloro-N-(4,4-diphenyl-butyl)-acetamide

N-(4,4-diphenylbutyl)nicotinamide

((1-cyclohexyl-1H-tetrazol-5-yl)methyl)-(4,4-diphenylbutyl)amine

Refernces

• 1、 Pandey, Ganesh,Laha, Ramkrishna,Mondal, Pradip Kumar. "Heterocyclization involving benzylic C(sp3)-H functionalization enabled by visible light photoredox catalysis". supporting information. p. 9689 - 9692. Retrieved 2019/08/15.
• 2、 Kowalczyk, Paula,Sa?at, Kinga,H?fner, Georg C.,Guzior, Natalia,Filipek, Barbara,Wanner, Klaus T.,Kulig, Katarzyna. "2-Substituted 4-hydroxybutanamides as potential inhibitors of γ-aminobutyric acid transporters mGAT1-mGAT4: Synthesis and biological evaluation". . p. 5154 - 5167. Retrieved 2013/09/02.