93007-58-0Relevant articles and documents
Br?nsted Acid-Initiated Formal [1,3]-Rearrangement Dictated by β-Substituted Ene-Aldimines
Jongwohan, Chanantida,Honda, Yasushi,Suzuki, Toshiyasu,Fujinami, Takeshi,Adachi, Kiyohiro,Momiyama, Norie
supporting information, p. 4991 - 4995 (2019/07/03)
The rearrangement of ene-aldimines is a useful reaction for affording homoallylic amines. Despite their utilities in synthetic chemistry, the rearrangement for accessing homoallylic amines substituted at the 2-position remains elusive. In this study, the
Palladium(II)-Catalyzed Regioselective syn-Hydroarylation of Disubstituted Alkynes Using a Removable Directing Group
Liu, Zhen,Derosa, Joseph,Engle, Keary M.
, p. 13076 - 13081 (2016/10/13)
A palladium(II)-catalyzed regioselective syn-hydroarylation reaction of homopropargyl amines has been developed, wherein selectivity is controlled by a cleavable bidentate directing group. Under the optimized reaction conditions, both dialkyl and alkylaryl alkyne substrates were found to undergo hydroarylation with high selectivity. The products of this reaction contain a 4,4-disubstituted homoallylic amine motif that is commonly seen in drug molecules and other bioactive compounds.
New synthesis of SKF 89976A
Chang, Meng-Yang,Wang, Si-Yun,Pai, Chun-Li
, p. 6389 - 6392 (2007/10/03)
Substituted 4,4-diaryl-3-butenyl-1-amines are synthesized in nearly 34-47% overall yields starting from 3-hydroxypiperidine by the regioselective Baeyer-Villiger lactonization, Grignard addition and elimination sequence. This facile strategy was also used