Technology Process of 1h-Pyrrole-3-carbohydrazide
There total 3 articles about 1h-Pyrrole-3-carbohydrazide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
thionyl chloride;
In
methanol;
at 50 ℃;
for 4h;
Cooling with ice;
With
hydrazine hydrate;
In
ethanol;
for 4h;
Reflux;
- Guidance literature:
-
1H-pyrrole-3-carboxylic acid;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
at 23 ℃;
for 2h;
Inert atmosphere;
With
hydrazine;
In
tetrahydrofuran;
at 23 ℃;
for 16h;
Inert atmosphere;
DOI:10.1016/j.bmcl.2013.11.081
