931-03-3

Basic information

• Product Name: Pyrrole-3-carboxylic acid
• Synonyms: Pyrrole-3-Carboxylic;1H-Pyrrole-3-carboxylic acid;Pyrrole-3-carboxylic acid;1H-PYRROLE-3-CARBOXYLIC ACID ANHYDROUS;1H-Pyrrole-3-carboxylate;Pyrrole-3-carboxylate;3-Carboxy-1H-pyrrole;1H-Pyrrole-3-carboxylic
• CAS NO: 931-03-3
• Molecular Formula: C₅H₅NO₂
• Molecular Weight: 111.1
• Product Categories: pharmacetical;Pyrrolidine series;Pyrrole&Pyrrolidine&Pyrroline;Benzenes;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Pyrroles
• Mol File: 931-03-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 209°C
• Boiling Point: 340.3 °C at 760 mmHg
• Flash Point: 159.6 °C
• Appearance: white to light yellow crystal powder
• Density: 1.383 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: pK1:4.453 (25°C)
• Water Solubility: Soluble in water.
• BRN: 108642
• CAS DataBase Reference: Pyrrole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrole-3-carboxylic acid(931-03-3)
• EPA Substance Registry System: Pyrrole-3-carboxylic acid(931-03-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 931-03-3(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

Pyrrole-3-carboxylic Acid is used in the preparation of isoindolinone compds. as cereblon inhibitors and GSPT1 degraders.

Definition

ChEBI: A pyrrolecarboxylic acid that is 1H-pyrrole substituted by a carboxy group at position 3. It has been isolated from Penicillium chrysogenum.

Upstream product

• 109-97-7 pyrrole 
• 124-38-9 carbon dioxide 
• 85684-93-1 1-tritylpyrrole-3-carboxylic acid 

Downstream Products

• 2703-17-5 methyl 1H-pyrrole-3-carboxylate 
• 191591-68-1 1-benzyl-1,4,5,6,7,8-hexahydropyrrolo-[3,2-c]azepine-4,8-dione 
• 191591-74-9 1-benzyl-5-(3-chloropropyl)-1,4,5,6, 7,8-hexahydropyrrolo[3,2-c]azepine-4,8-dione 
• 191591-89-6 1-ethyl-5-[3-[4-(4-fluorophenyl)-piperazin-1-yl]propyl]-1,4,5,6,7,8-hexahydropyrrolo-[3,2-c]azepine-4,8-dione 
• 191591-91-0 1-benzyl-5-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-1,4,5,6,7,8-hexahydropyrrolo[3,2-c]azepine-4,8-dione 
• 658695-85-3 5-(1H-pyrazolo[3,4-b]pyrid-3-yl)-1H-pyrrole-3-carboxylic acid 

Relevant articles and documents

Carboxylation of indoles and pyrroles with CO2 in the presence of dialkylaluminum halides

The Lewis acid-mediated carboxylation of arenes with CO2 has been successfully applied to 1-substituted indoles and pyrroles by using dialkylaluminum chlorides instead of aluminum trihalides. Thus, the carboxylation of 1-methylindoles, 1-benzyl-, and 1-phenylpyrroles proceeds regioselectively with the aid of an equimolar amount of Me2AlCl under CO2 pressure (3.0 MPa) at room temperature to afford the corresponding indole-3-carboxylic acids and pyrrole-2-carboxylic acids in 61-85% yields, while the same treatment of 1,2,5-trimethylpyrrole affords the 3-carboxylic acid in 52% yield.