2-Amino-5-sulfamoylbenzoic acid

Base Information

• Chemical Name: 2-Amino-5-sulfamoylbenzoic acid
• CAS No.: 137-65-5
• Molecular Formula: C7H8N2O4S
• Molecular Weight: 216.218
• Hs Code.: 2935009090
• European Community (EC) Number: 205-304-9
• DSSTox Substance ID: DTXSID9059678
• Nikkaji Number: J64.459E
• Wikidata: Q72437793
• Mol file: 137-65-5.mol

Synonyms:2-amino-5-sulfamoylbenzoic acid;137-65-5;2-Amino-5-(aminosulphonyl)benzoic acid;Benzoic acid, 2-amino-5-(aminosulfonyl)-;2-Amino benzoic acid-5-sulfonamide;2-aminobenzoic acid-5-sulfonamide;EINECS 205-304-9;5-sulphamoylanthranilic acid;SCHEMBL344115;DTXSID9059678;GS1164;AKOS009075641;CS-0240128;FT-0607315;EN300-22542;W-108232;Z147646752

Chemical Property of 2-Amino-5-sulfamoylbenzoic acid

Chemical Property:

• Appearance/Colour: white crystal
• Vapor Pressure: 1.38E-11mmHg at 25°C
• Melting Point: 246 °C (decomp)
• Refractive Index: 1.658
• Boiling Point: 518.744 °C at 760 mmHg
• PKA: 4.41±0.10(Predicted)
• Flash Point: 267.527 °C
• PSA: 131.86000
• Density: 1.623 g/cm³
• LogP: 1.97670
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 216.02047791
• Heavy Atom Count: 14
• Complexity: 321

Purity/Quality:

99%, ^*data from raw suppliers

2-Amino-5-sulfamoylbenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1S(=O)(=O)N)C(=O)O)N

Technology Process of 2-Amino-5-sulfamoylbenzoic acid

There total 5 articles about 2-Amino-5-sulfamoylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetylamino-5-sulfamoyl-benzoic acid → 2-amino-5-sulfamoylbenzoic acid (137-65-5)

Guidance literature:

With hydrogenchloride;

Reference yield:

2-hydroxyoxalylamino-5-sulfamoyl-benzoic acid → 2-amino-5-sulfamoylbenzoic acid (137-65-5)

Guidance literature:

With sodium hydroxide;

Reference yield:

N-[4-(aminosulfonyl)-2-methylphenyl]acetamide (252562-03-1) → 2-amino-5-sulfamoylbenzoic acid (137-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous KMnO₄

2: aqueous HCl

With hydrogenchloride; potassium permanganate;

upstream raw materials:

methanol

4-chloro-2-furfurylamino-5-sulfamoyl-benzoic acid

N-[4-(aminosulfonyl)-2-methylphenyl]acetamide

Refernces