5-Chloro-3-(2-aminopropyl)indole

Base Information

Chemical Name:5-Chloro-3-(2-aminopropyl)indole
CAS No.:712-07-2
Molecular Formula:C11H13ClN2
Molecular Weight:208.6873
Hs Code.:
UNII:UZN5KF293Y
DSSTox Substance ID:DTXSID10991511
Wikipedia:5-Chloro-%CE%B1MT
Wikidata:Q19877216
Pharos Ligand ID:DC7GZPLP94Q7
ChEMBL ID:CHEMBL1906905

Synonyms:5-Chloro-3-(2-aminopropyl)indole;5-Chloro-alphaMT;712-07-2;1-(5-chloro-1H-indol-3-yl)propan-2-amine;INDOLE, 3-(2-AMINOPROPYL)-5-CHLORO-;BRN 0475946;UZN5KF293Y;CHEMBL1906905;UNII-UZN5KF293Y;5-CHLORO-.ALPHA.MT;Oprea1_540078;SCHEMBL1305546;DTXSID10991511;BDBM50025221;STL429757;AKOS005174851;NCGC00245687-01;LS-82326;Q19877216;5-CHLORO-.ALPHA.-METHYL-1H-INDOLE-3-ETHANAMINE;1H-INDOLE-3-ETHANAMINE, 5-CHLORO-.ALPHA.-METHYL-

Suppliers and Price of 5-Chloro-3-(2-aminopropyl)indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 5-Chloro-3-(2-aminopropyl)indole

Chemical Property:

Vapor Pressure:6.98E-06mmHg at 25°C
Boiling Point:377°C at 760 mmHg
Flash Point:181.8°C
Density:1.248g/cm³
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:208.0767261
Heavy Atom Count:14
Complexity:198

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC1=CNC2=C1C=C(C=C2)Cl)N

Technology Process of 5-Chloro-3-(2-aminopropyl)indole

There total 4 articles about 5-Chloro-3-(2-aminopropyl)indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.9%

: 835-49-4
C₁₁H₉ClN₂O₂

: 712-07-2
5-Chlor-3-(2-amino-propyl)-indol

Guidance literature:: C₁₁H₉ClN₂O₂; With lithium aluminium tetrahydride; In tetrahydrofuran; at 90 ℃;

With water; sodium hydroxide; In tetrahydrofuran; Cooling with ice;

Reference yield:

: 17422-32-1
5-chloro-1H-indole

: 712-07-2
5-Chlor-3-(2-amino-propyl)-indol

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 0.17 h / 20 °C

1.2: 1.25 h / 20 °C

1.3: 0.13 h / 100 °C

2.1: ammonium acetate / 18 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / Reflux

With lithium aluminium tetrahydride; ammonium acetate; trichlorophosphate; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2014.07.062

Reference yield:

: 827-01-0
5-chloro-1H-indole-3-carboxaldehyde

: 712-07-2
5-Chlor-3-(2-amino-propyl)-indol

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / 18 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / Reflux

With lithium aluminium tetrahydride; ammonium acetate; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2014.07.062