2-(3-Thienyl)pyridine

Base Information

• Chemical Name: 2-(3-Thienyl)pyridine
• CAS No.: 21298-55-5
• Molecular Formula: C9H7 N S
• Molecular Weight: 161.227
• Hs Code.: 2934999090
• European Community (EC) Number: 244-322-1
• DSSTox Substance ID: DTXSID00175565
• Nikkaji Number: J209.029E
• Wikidata: Q83045925
• Mol file: 21298-55-5.mol

Synonyms:2-(3-Thienyl)pyridine;21298-55-5;2-(thiophen-3-yl)pyridine;2-thiophen-3-ylpyridine;MFCD00006214;EINECS 244-322-1;3-(2-Pyridyl)thiophene;SCHEMBL597347;Pyridine, 2-(thiophen-3-yl)-;DTXSID00175565;AKOS004118750;CS-W013263;SB53822;AS-58457;FT-0638106;T1151;T72074

Chemical Property of 2-(3-Thienyl)pyridine

Chemical Property:

• Vapor Pressure: 0.0599mmHg at 25°C
• Melting Point: 25°C
• Boiling Point: 240.1°Cat760mmHg
• PKA: 5.04±0.12(Predicted)
• Flash Point: 96.8°C
• PSA: 41.13000
• Density: 1.173g/cm³
• LogP: 2.81010
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 161.02992040
• Heavy Atom Count: 11
• Complexity: 127

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Thiophen-3-ylpyridine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C2=CSC=C2

Technology Process of 2-(3-Thienyl)pyridine

There total 25 articles about 2-(3-Thienyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-chloropyridine (109-09-1) + Thien-3-ylboronic acid (6165-69-1) → 3-(2-pyridyl)thiophene (21298-55-5)

Guidance literature:

With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; tetrabutylammomium bromide; sodium hydrogencarbonate; In water; for 1h; Catalytic behavior; Reflux;

DOI:10.1039/c3dt32860k

Reference yield: 97.0%

2-bromo-pyridine (109-04-6) + Thien-3-ylboronic acid (6165-69-1) → 3-(2-pyridyl)thiophene (21298-55-5)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); N,N,N′,N′-tetra(diphenylphosphinomethyl)-1,2-ethylenediamine; potassium carbonate; In N,N-dimethyl acetamide; butan-1-ol; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1002/aoc.2965

Reference yield: 97.0%

2-bromo-pyridine (109-04-6) + 3-thiophenyl boronic acid → 3-(2-pyridyl)thiophene (21298-55-5)

Guidance literature:

With bis(triphenylphosphine)palladium(II) dichloride; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 14h;

DOI:10.1002/chem.201304314

upstream raw materials:

thiophene

2-bromo-pyridine

2-iodopyridine

3-Bromothiophene

Downstream raw materials:

bis{3-(2-pyridyl)-2-thienyl}diphenyltin(IV)

{3-(2-pyridyl)-2-thienyl}diphenyltin hydroxide

bis{3-(2-pyridyl)-2-thienyl-C,N}diphenyltin

{3-(2-pyridyl)-2-thienyl}di(p-tolyl)tin bromide