2-Fluoroformycin

Base Information

Chemical Name:2-Fluoroformycin
CAS No.:97782-08-6
Molecular Formula:C₁₀H₁₂FN₅O₄
Molecular Weight:285.235
Hs Code.:
DSSTox Substance ID:DTXSID30913654
Wikidata:Q82884311
ChEMBL ID:CHEMBL3144006
Mol file:97782-08-6.mol

Synonyms:2-fluoroformycin;7-amino-5-fluoro-3-(beta-ribofuranosyl)pyrazolo(4,3-d)pyrimidine

Suppliers and Price of 2-Fluoroformycin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-Fluoroformycin

Chemical Property:

Vapor Pressure:9.59E-15mmHg at 25°C
Melting Point:300 °C
Boiling Point:589.6°Cat760mmHg
Flash Point:310.4°C
PSA：150.40000
Density:1.839g/cm³
LogP:-1.19060
XLogP3:-1.8
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:285.08733204
Heavy Atom Count:20
Complexity:367

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C(C1C(C(C(O1)C2=C3C(=NN2)C(=NC(=N3)F)N)O)O)O
Isomeric SMILES:C([C@@H]1[C@H]([C@H]([C@@H](O1)C2=C3C(=NN2)C(=NC(=N3)F)N)O)O)O

Technology Process of 2-Fluoroformycin

There total 2 articles about 2-Fluoroformycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 97782-03-1
5,7-diamino-(3-β-D-ribofuranosyl)pyrazolo<4,3-d>pyrimidine

: 97782-08-6
7-amino-5-fluoro-(3-β-D-ribofuranosyl)pyrazolo<4,3-d>pyrimidine

Guidance literature:: With pyridine; tert.-butylnitrite; hydrogen fluoride; at -20 ℃; for 2h;
DOI:10.1021/jm00149a033

Reference yield:

: 80206-18-4
5-amino-3-(β-D-ribofuranosyl)-1H-pyrazolo<4,3-d>pyrimidin-7(6H)-one

: 97782-08-6
7-amino-5-fluoro-(3-β-D-ribofuranosyl)pyrazolo<4,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) acetic anhydride, pyridine, 2.) tetraethylammonium chloride, N,N-dimethylaniline, phosphorus oxychloride, 3.) sat. ammonia in ethanol

2: 19 percent / HF, pyridine, tert-butyl nitrite / 2 h / -20 °C

With pyridine; tert.-butylnitrite; hydrogen fluoride; tetraethylammonium chloride; acetic anhydride; N,N-dimethyl-aniline; ammonia ethyl alcohol; trichlorophosphate;
DOI:10.1021/jm00149a033