N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide

Base Information

• Chemical Name: N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide
• CAS No.: 13053-83-3
• Molecular Formula: C5H7 N3 O S
• Molecular Weight: 157.196
• Mol file: 13053-83-3.mol

Synonyms:1,3,4-Thiadiazole,2-acetamido-5-methyl- (6CI,7CI); 2-Acetamido-5-methyl-1,3,4-thiadiazole; NSC34804

Chemical Property of N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide

Chemical Property:

• Density: 1.37g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide

There total 2 articles about N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

acetic anhydride (108-24-7) + 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone (75843-20-8) → 4-hydroxy-6-methyl-2-pyron (675-10-5) + N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide (13053-83-3)

Guidance literature:

for 0.166667h; Heating;

Reference yield: 26.0%

acetic anhydride (108-24-7) + 2-(β-D-galactopyranosyl)hydrazinecarbothioamide (154634-26-1,154634-24-9) → N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide (13053-83-3) + (-)-5-acetamido-3-N-acetyl-2-(1,2,3,4,5-penta-O-acetyl-D-galacto-pentitol-1-yl)-1,3,4-thiadiazoline (71952-23-3,72002-46-1,115510-62-8) + β-D-galactose peracetate (4163-60-4)

Guidance literature:

for 4h; Product distribution; Heating;

DOI:10.1016/S0008-6215(00)00127-0

Reference yield:

N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide (13053-83-3) → 5-methyl-1,3,4-thiadiazol-2-amine (108-33-8)

Guidance literature:

With sulfuric acid; In water; Heating;

upstream raw materials:

acetic anhydride

3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone

2-(β-D-galactopyranosyl)hydrazinecarbothioamide

Downstream raw materials:

2-(ethylamino)-5-methyl-1,3,4-thiadiazole

5-methyl-1,3,4-thiadiazol-2-amine