3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone

Base Information

• Chemical Name: 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone
• CAS No.: 75843-20-8
• Molecular Formula: C₉H₁₁N₃O₃S
• Molecular Weight: 241.271
• Mol file: 75843-20-8.mol

Synonyms:3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone

Chemical Property of 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone

There total 2 articles about 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one (771-03-9) + thiosemicarbazide (79-19-6) → 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone (75843-20-8)

Guidance literature:

In ethanol; Reflux;

DOI:10.1007/s00044-011-9859-y DOI:10.2298/JSC160310002M

Reference yield:

thiosemicarbazide (79-19-6) + Dehydracetic acid (520-45-6,53488-80-5) → 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone (75843-20-8)

Guidance literature:

In ethanol; for 3h; Heating;

DOI:10.1016/j.jorganchem.2008.03.023

Reference yield: 76.0%

α-bromoacetophenone (70-11-1) + 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one thiosemicarbazone (75843-20-8) → 4-hydroxy-6-methyl-3-(1-(2-(4-phenylthiazol-2-yl)hydrazono)ethyl)-2H-pyran-2-one (151504-48-2)

Guidance literature:

With sodium acetate; In ethanol; for 0.5h; Reflux;

DOI:10.1007/s00044-011-9859-y

upstream raw materials:

thiosemicarbazide

Dehydracetic acid

3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one

Downstream raw materials:

4-hydroxy-6-methyl-2-pyron

N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide

N-(5-methyl-1,3,4-thiadiazol-2-yl)-propionamide

3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one