POLY-S-CBZ-L-CYSTEINE MOL WT 5000-15000

Base Information

• Chemical Name: POLY-S-CBZ-L-CYSTEINE MOL WT 5000-15000
• CAS No.: 29663-62-5
• Molecular Formula: C₁₁H₁₃NO₄S
• Molecular Weight: 255.295
• Mol file: 29663-62-5.mol

Synonyms:

Chemical Property of POLY-S-CBZ-L-CYSTEINE MOL WT 5000-15000

Chemical Property:

• Storage Temp.: −20°C

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of POLY-S-CBZ-L-CYSTEINE MOL WT 5000-15000

There total 5 articles about POLY-S-CBZ-L-CYSTEINE MOL WT 5000-15000 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

L-Cysteine (52-90-4) + dimethylsulfonium methyl sulfate → S-(benzyloxycarbonyl)-L-cysteine (1625-72-5,29663-62-5)

Guidance literature:

With triethylamine; at 20 ℃; for 5h;

DOI:10.1246/bcsj.62.3103

Reference yield:

l-cysteine hydrochloride (52-89-1) → S-(benzyloxycarbonyl)-L-cysteine (1625-72-5,29663-62-5)

Guidance literature:

With sodium hydrogencarbonate; anschliessendes Behandeln mit Chlorokohlensaeure-benzylester;

DOI:10.1021/ja01598a079

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → S-(benzyloxycarbonyl)-L-cysteine (1625-72-5,29663-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Et₃N / acetonitrile / 2 h / 5 °C

2: 61 percent / Et₃N / 5 h / 20 °C

With triethylamine; In acetonitrile;

DOI:10.1246/bcsj.62.3103

upstream raw materials:

l-cysteine hydrochloride

L-Cysteine

benzyl chloroformate

Refernces

• 1、 Azuse,Tamura,Kinomura,Okai,Kouge,Hamatsu,Koizumi. "Peptide synthesis in aqueous solution. IV. Preparation and properties of [p-(benzyloxycarbonyloxy)phenyl]dimethylsulfonium methyl sulfate, [p-(t-butoxycarbonyloxy)phenyl]dimethylsulfonium methyl sulfate and [p-(9-fluorenylmethyl-oxycarbonyloxy)phenyl]dimethylsulfonium methyl sulfate as water-soluble N-acylating reagents". . p. 3103 - 3108. Retrieved 2007/10/02.