(2,8-Bis(trifluoromethyl)quinolin-4-yl)(pyridin-2-yl)methanone

Base Information

Chemical Name:(2,8-Bis(trifluoromethyl)quinolin-4-yl)(pyridin-2-yl)methanone
CAS No.:35853-55-5
Molecular Formula:C17H8F6N2O
Molecular Weight:370.254
Hs Code.:2933990090
European Community (EC) Number:252-763-6
UNII:F292WNT81D
Nikkaji Number:J319.549J
Mol file:35853-55-5.mol

Synonyms:35853-55-5;(2,8-bis(trifluoromethyl)quinolin-4-yl)(pyridin-2-yl)methanone;C17H8F6N2O;(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanone;2-PYRIDYL 2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLYL KETONE;Bis[2,8-di(trifluoromethyl)quinolin-4-yl-2-pyridyl]ketone;SCHEMBL2847208;[2,8-bis(trifluoromethyl)quinolin-4-yl]-pyridin-2-yl-methanone;BCP11853;C17-H8-F6-N2-O;MFCD05863551;AKOS015950923;AB22512;DS-11041;FT-0646817;A26937;C74844;A823001;J-500613;MEFLOQUINE HYDROCHLORIDE IMPURITY B [WHO-IP];2-Pyridyl2,8-bis(trifluoromethyl)-4-quinolyl ketone;[2,8-Bis(trifluoromethyl)-4-quinolyl]2-pyridyl ketone;MEFLOQUINE HYDROCHLORIDE IMPURITY A [EP IMPURITY];pyrid-2-yl 2,8-bis-(trifluoromethyl)-quinolin-4-yl ketone;(2,8-Bis-trifluoromethylquinolin-4-yl)pyridin-2-ylmethanone;[2,8-bis(trifluoromethyl)-4-quinolyl]-(2-pyridyl)methanone;[2,8-bis(trifluoromethyl)-4-quinolinyl]-(2-pyridinyl)methanone;(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanone, AldrichCPR;METHANONE, (2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLINYL)-2-PYRIDINYL-

Suppliers and Price of (2,8-Bis(trifluoromethyl)quinolin-4-yl)(pyridin-2-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
[2,8-Bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone
100mg
$ 95.00

SynQuest Laboratories
(2,8-Bis-trifluoromethylquinolin-4-yl)pyridin-2-ylmethanone
5 g
$ 928.00

SynQuest Laboratories
(2,8-Bis-trifluoromethylquinolin-4-yl)pyridin-2-ylmethanone
1 g
$ 312.00

Sigma-Aldrich
(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanone Aldrich
1g
$ 194.00

Matrix Scientific
(2,8-Bis(trifluoromethyl)quinolin-4-yl)(pyridin-2-yl)methanone 95+%
1g
$ 471.00

Matrix Scientific
(2,8-Bis(trifluoromethyl)quinolin-4-yl)(pyridin-2-yl)methanone 95+%
250mg
$ 213.00

Crysdot
(2,8-Bis(trifluoromethyl)quinolin-4-yl)(pyridin-2-yl)methanone 95+%
5g
$ 743.00

Chemenu
(2,8-bis(trifluoromethyl)quinolin-4-yl)(pyridin-2-yl)methanone 95%
1g
$ 191.00

Chemenu
(2,8-bis(trifluoromethyl)quinolin-4-yl)(pyridin-2-yl)methanone 95%
5g
$ 701.00

American Custom Chemicals Corporation
(2,8-BIS(TRIFLUOROMETHYL)QUINOLIN-4-YL)(PYRIDIN-2-YL)METHANONE 95.00%
5MG
$ 505.80

Total 31 raw suppliers

Chemical Property of (2,8-Bis(trifluoromethyl)quinolin-4-yl)(pyridin-2-yl)methanone

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.54
Boiling Point:427.828 °C at 760 mmHg
Flash Point:212.543 °C
PSA：42.85000
Density:1.451 g/cm³
LogP:4.89840
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:4.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:370.05408186
Heavy Atom Count:26
Complexity:520

Purity/Quality:

99.9% ^*data from raw suppliers

[2,8-Bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=NC(=C1)C(=O)C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F
Uses [2,8-Bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone is an intermediate in the synthesis of Mefloquine Hydrochloride (M207052) which is a labelled quinoline methanol antimalarial agent.

Technology Process of (2,8-Bis(trifluoromethyl)quinolin-4-yl)(pyridin-2-yl)methanone

There total 16 articles about (2,8-Bis(trifluoromethyl)quinolin-4-yl)(pyridin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 138058-60-3
α-Hydroxy-α-(2-pyridyl)-2,8-bis(trifluoromethyl)-4-quinolylacetonitrile

: 35853-55-5
[2,8-bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone

Guidance literature:: With sodium hydroxide; In diethyl ether; for 0.166667h; Ambient temperature;
DOI:10.1016/S0040-4020(01)88284-3

Reference yield: 95.0%

: 83012-12-8
α-(2-Pyridyl)-2,8-bis(trifluoromethyl)-4-quinolylacetonitrile

: 35853-55-5
[2,8-bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone

Guidance literature:: With dihydrogen peroxide; acetic acid; at 70 ℃; for 1h;
DOI:10.1016/S0040-4020(01)88284-3

Reference yield: 63.0%

: 4-(pyridin-2-ylmethyl)-2,8-bis(trifluoromethyl)quinoline

: 35853-55-5
[2,8-bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone

Guidance literature:: With iron(II) chloride tetrahydrate; oxygen; acetic acid; In dimethyl sulfoxide; at 100 ℃; for 24h; under 760.051 Torr;
DOI:10.3762/bjoc.12.16